SCOPe 2.05: Domain d3s2aa4: 3s2a A:726-1088

Lineage for d3s2aa4 (3s2a A:726-1088)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.4: Phoshoinositide 3-kinase (PI3K), catalytic domain [56171] (1 protein)

6. Protein Phoshoinositide 3-kinase (PI3K), catalytic domain [56172] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56174] (58 PDB entries)

8. Domain d3s2aa4: 3s2a A:726-1088 [249288]
   Other proteins in same PDB: d3s2aa1, d3s2aa2, d3s2aa3
   automated match to d1e7ua4
   complexed with 2nq, so4

Details for d3s2aa4

PDB Entry: 3s2a, 2.55 Å

PDB Description: Crystal structure of PI3K-gamma in complex with a quinoline inhibitor

PDB Compounds: (A:) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d3s2aa4:

Sequence, based on SEQRES records:

>d3s2aa4 d.144.1.4 (A:726-1088) Phoshoinositide 3-kinase (PI3K), catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
tamlhdftqqvqviemlqkvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrv
pydpglkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlil
qilrimesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkde
vlnhwlkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidf
ghilgnyksflginkervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtn
lliilfsmmlmtgmpqltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfn
wfl

Sequence, based on observed residues (ATOM records):

>d3s2aa4 d.144.1.4 (A:726-1088) Phoshoinositide 3-kinase (PI3K), catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
tamlhdftqqvqviemlqkvtldikslsaedvssqvisqlkqklenlqnsqlpesfrvpy
dpglkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqi
lrimesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkdevl
nhwlkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfgh
ikervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtg
mpqltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwfl

Timeline for d3s2aa4:

• d3s2aa4 first appeared in SCOPe 2.04
  
• d3s2aa4 appears in SCOPe 2.06
  
• d3s2aa4 appears in the current release, SCOPe 2.08