SCOPe 2.07: Domain d2pzra_: 2pzr A:

Lineage for d2pzra_ (2pzr A:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Fibroblast growth factor receptor 2 [75562] (1 species)
   PTK group; FGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [75563] (16 PDB entries)
   Uniprot P21802 467-765

8. Domain d2pzra_: 2pzr A: [243508]
   automated match to d4nkab_
   complexed with acp, so4; mutant

Details for d2pzra_

PDB Entry: 2pzr, 3 Å

PDB Description: crystal structure of fgf receptor 2 (fgfr2) kinase domain harboring the pathogenic k641r mutation responsible for pfeiffer syndrome

PDB Compounds: (A:) Fibroblast growth factor receptor 2

SCOPe Domain Sequences for d2pzra_:

Sequence, based on SEQRES records:

>d2pzra_ d.144.1.7 (A:) Fibroblast growth factor receptor 2 {Human (Homo sapiens) [TaxId: 9606]}
lpedpkwefprdkltlgkplgegafgqvvmaeavgidkdkpkeavtvavkmlkddatekd
lsdlvsememmkmigkhkniinllgactqdgplyviveyaskgnlreylrarrppgmeys
ydinrvpeeqmtfkdlvsctyqlargmeylasqkcihrdlaarnvlvtennvmriadfgl
ardinnidyykkttngrlpvkwmapealfdrvythqsdvwsfgvlmweiftlggspypgi
pveelfkllkeghrmdkpanctnelymmmrdcwhavpsqrptfkqlvedldriltltt

Sequence, based on observed residues (ATOM records):

>d2pzra_ d.144.1.7 (A:) Fibroblast growth factor receptor 2 {Human (Homo sapiens) [TaxId: 9606]}
lpedpkwefprdkltlgkplqvvmaeavgidkdkpkeavtvavkmlkddatekdlsdlvs
ememmkmigkhkniinllgactqdgplyviveyaskgnlreylrarrppeeqmtfkdlvs
ctyqlargmeylasqkcihrdlaarnvlvtennvmriadfglardinnidyykkttngrl
pvkwmapealfdrvythqsdvwsfgvlmweiftlggspypgipveelfkllkeghrmdkp
anctnelymmmrdcwhavpsqrptfkqlvedldriltltt

Timeline for d2pzra_:

• d2pzra_ first appeared in SCOPe 2.04
  
• d2pzra_ appears in SCOPe 2.06
  
• d2pzra_ appears in the current release, SCOPe 2.08