PDB entry 2pzr

View 2pzr on RCSB PDB site
Description: Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K641R Mutation Responsible for Pfeiffer Syndrome
Class: transferase
Keywords: Kinase Domain Fold Consisting of N- and C-lobes, transferase
Deposited on 2007-05-18, released 2007-09-25
The last revision prior to the SCOPe 2.07 freeze date was dated 2016-12-21, with a file datestamp of 2016-12-16.
Experiment type: XRAY
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Fibroblast growth factor receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: FGFR2, BEK, KSAM
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21802
      • engineered (196)
    Domains in SCOPe 2.07: d2pzra_
  • Chain 'B':
    Compound: Fibroblast growth factor receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: FGFR2, BEK, KSAM
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21802
      • engineered (196)
    Domains in SCOPe 2.07: d2pzrb_
  • Heterogens: SO4, ACP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2pzrA (A:)
mgsshhhhhhsqdpmlagvseyelpedpkwefprdkltlgkplgegafgqvvmaeavgid
kdkpkeavtvavkmlkddatekdlsdlvsememmkmigkhkniinllgactqdgplyviv
eyaskgnlreylrarrppgmeysydinrvpeeqmtfkdlvsctyqlargmeylasqkcih
rdlaarnvlvtennvmriadfglardinnidyykkttngrlpvkwmapealfdrvythqs
dvwsfgvlmweiftlggspypgipveelfkllkeghrmdkpanctnelymmmrdcwhavp
sqrptfkqlvedldriltlttnee

    Sequence, based on observed residues (ATOM records): (download) 
    >2pzrA (A:)
lpedpkwefprdkltlgkplqvvmaeavgidkdkpkeavtvavkmlkddatekdlsdlvs
ememmkmigkhkniinllgactqdgplyviveyaskgnlreylrarrppeeqmtfkdlvs
ctyqlargmeylasqkcihrdlaarnvlvtennvmriadfglardinnidyykkttngrl
pvkwmapealfdrvythqsdvwsfgvlmweiftlggspypgipveelfkllkeghrmdkp
anctnelymmmrdcwhavpsqrptfkqlvedldriltltt

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2pzrB (B:)
mgsshhhhhhsqdpmlagvseyelpedpkwefprdkltlgkplgegafgqvvmaeavgid
kdkpkeavtvavkmlkddatekdlsdlvsememmkmigkhkniinllgactqdgplyviv
eyaskgnlreylrarrppgmeysydinrvpeeqmtfkdlvsctyqlargmeylasqkcih
rdlaarnvlvtennvmriadfglardinnidyykkttngrlpvkwmapealfdrvythqs
dvwsfgvlmweiftlggspypgipveelfkllkeghrmdkpanctnelymmmrdcwhavp
sqrptfkqlvedldriltlttnee

    Sequence, based on observed residues (ATOM records): (download) 
    >2pzrB (B:)
elpedpkwefprdkltlgkplqvvmaeavgidkdkpkeavtvavkmlkddatekdlsdlv
sememmkmigkhkniinllgactqdgplyviveyaskgnlreylrarrppeeqmtfkdlv
sctyqlargmeylasqkcihrdlaarnvlvtennvmriadfglardinnidyykkttngr
lpvkwmapealfdrvythqsdvwsfgvlmweiftlggspypgipveelfkllkeghrmdk
panctnelymmmrdcwhavpsqrptfkqlvedldriltlttn