SCOPe 2.04: Domain d4eo8a_: 4eo8 A:

Lineage for d4eo8a_ (4eo8 A:)

1. Root: SCOPe 2.04

2. Class e: Multi-domain proteins (alpha and beta) [56572] (68 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (7 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.4: RNA-dependent RNA-polymerase [56694] (3 proteins)

6. Protein Viral RNA polymerase [56695] (17 species)

7. Species Hepatitis C virus isolate bk [TaxId:11105] [195056] (4 PDB entries)

8. Domain d4eo8a_: 4eo8 A: [220755]
   automated match to d4eo6b_
   protein/RNA complex; complexed with 0s3

Details for d4eo8a_

PDB Entry: 4eo8, 1.8 Å

PDB Description: HCV NS5B polymerase inhibitors: Tri-substituted acylhydrazines as tertiary amide bioisosteres

PDB Compounds: (A:) RNA-directed RNA polymerase

SCOPe Domain Sequences for d4eo8a_:

Sequence, based on SEQRES records:

>d4eo8a_ e.8.1.4 (A:) Viral RNA polymerase {Hepatitis C virus isolate bk [TaxId: 11105]}
hhsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
svwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiy
qccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkas
aacraaklqdctmlvngddlvvicesagvqedaaslrafteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspg
einrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpip
aasqldlsgwfvagysggdiyh

Sequence, based on observed residues (ATOM records):

>d4eo8a_ e.8.1.4 (A:) Viral RNA polymerase {Hepatitis C virus isolate bk [TaxId: 11105]}
hhsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
svwkdlledtvtpidttimaknevfcvqrkparlivfpdlgvrvcekmalydvvstlpqv
vmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiyqccdl
apearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkasaacra
aklqdctmlvngddlvvicesagvqedaaslrafteamtrysappgdppqpeydlelits
cssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlwarmil
mthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspgeinrv
asclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpipaasql
dlsgwfvagysggdiyh

Timeline for d4eo8a_:

• d4eo8a_ first appeared in SCOPe 2.03
  
• d4eo8a_ appears in SCOPe 2.05
  
• d4eo8a_ appears in the current release, SCOPe 2.08, called d4eo8a1