SCOPe 2.04: Domain d4e76a_: 4e76 A:

Lineage for d4e76a_ (4e76 A:)

1. Root: SCOPe 2.04

2. Class e: Multi-domain proteins (alpha and beta) [56572] (68 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (7 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.4: RNA-dependent RNA-polymerase [56694] (3 proteins)

6. Protein Viral RNA polymerase [56695] (17 species)

7. Species Hepatitis C virus [TaxId:356411] [193797] (2 PDB entries)

8. Domain d4e76a_: 4e76 A: [220341]
   automated match to d4e78a_
   complexed with edo, so4

Details for d4e76a_

PDB Entry: 4e76, 2.5 Å

PDB Description: apo crystal structure of hcv ns5b genotype 2a jfh-1 isolate with beta hairpin loop deletion

PDB Compounds: (A:) RNA-directed RNA polymerase

SCOPe Domain Sequences for d4e76a_:

Sequence; same for both SEQRES and ATOM records:

>d4e76a_ e.8.1.4 (A:) Viral RNA polymerase {Hepatitis C virus [TaxId: 356411]}
ssmsyswtgalitpcspeeeklpinplsnsllryhnkvycttsksasqrakkvtfdrtqv
ldahydsvlkdiklaaskvsarlltlqqacqltpphsarskygfgakevrslsgravnhi
ksvwkdlledpqtpipttimaknevfcvdpakggkkparlivypdlgvrvcekmalydit
qklpqavmgasygfqyspaqrveyllkawaekkdpmgfsydtrcfdstvterdirteesi
yqacslpeeartaihslterlyvggpmfnskgqtcgyrrcrasgvlttsmgntitcyvka
laackaagivaptmlvcgddlvvisesqgteedernlrafteamtrysappgdpprpeyd
lelitscssnvsvalgprgrrryyltrdpttplaraawetvrhspinswlgniiqyapti
wvrmvlmthffsilmvqdtldqnlggvnpldlpaiierlhgldafsmhtyshheltrvas
alrklgapplrvwksraravraslisrggkaavcgrylfnwavktklkltplpearlldl
sswf

Timeline for d4e76a_:

• d4e76a_ first appeared in SCOPe 2.03
  
• d4e76a_ appears in SCOPe 2.05
  
• d4e76a_ appears in the current release, SCOPe 2.08, called d4e76a1