SCOPe 2.05: Domain d3slsa_: 3sls A:

Lineage for d3slsa_ (3sls A:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (12 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (553 PDB entries)

8. Domain d3slsa_: 3sls A: [216479]
   automated match to d1s9ia_
   complexed with 77d, anp, mg

Details for d3slsa_

PDB Entry: 3sls, 2.3 Å

PDB Description: Crystal Structure of human MEK-1 kinase in complex with UCB1353770 and AMPPNP

PDB Compounds: (A:) Dual specificity mitogen-activated protein kinase kinase 1

SCOPe Domain Sequences for d3slsa_:

Sequence, based on SEQRES records:

>d3slsa_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
mtlqqrkrleafltqkqkvgelkdddfekiselgagnggvvfkvshkpsglvmarklihl
eikpairnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldqvlkkagri
peqilgkvsiavikgltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlidsman
sfvgtrsymsperlqgthysvqsdiwsmglslvemavgrypigsgsgsmaifelldyivn
epppklpsgvfslefqdfvnkcliknpaeradlkqlmvhafikrsdaeevdfagwlcsti
glnq

Sequence, based on observed residues (ATOM records):

>d3slsa_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
mtlqqrkrleafltqkqkvgelkdddfekiselgagnggvvfkvshkpsglvmarklihl
eikpairnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldqvlkkagri
peqilgkvsiavikgltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlifvgtr
symsperlqgthysvqsdiwsmglslvemavgrypigaifelldyivnepppklpsgvfs
lefqdfvnkcliknpaeradlkqlmvhafikrsdaeevdfagwlcstiglnq

Timeline for d3slsa_:

• d3slsa_ first appeared in SCOPe 2.03
  
• d3slsa_ appears in SCOPe 2.04
  
• d3slsa_ is called d3slsa1 in SCOPe 2.06
  
• d3slsa_ appears in the current release, SCOPe 2.08, called d3slsa1