SCOPe 2.05: Domain d3skaa_: 3ska A:

Lineage for d3skaa_ (3ska A:)

1. Root: SCOPe 2.05

2. Class e: Multi-domain proteins (alpha and beta) [56572] (68 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (7 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.4: RNA-dependent RNA-polymerase [56694] (3 proteins)

6. Protein automated matches [190260] (26 species)
   not a true protein

7. Species Hepatitis C virus [TaxId:420174] [189885] (4 PDB entries)

8. Domain d3skaa_: 3ska A: [216429]
   Other proteins in same PDB: d3skab_
   automated match to d3upha_
   protein/RNA complex; complexed with 053, po4

Details for d3skaa_

PDB Entry: 3ska, 1.73 Å

PDB Description: I. Novel HCV NS5B Polymerase Inhibitors: Discovery of Indole 2- Carboxylic Acids with C3-Heterocycles

PDB Compounds: (A:) hcv ns5b rna_dependent RNA polymerase

SCOPe Domain Sequences for d3skaa_:

Sequence, based on SEQRES records:

>d3skaa_ e.8.1.4 (A:) automated matches {Hepatitis C virus [TaxId: 420174]}
smsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhir
svwedlledtetpidttimaksevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiy
qccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkat
aacraaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlw
armilmthffsillaqeqlgkaldcqiygacysiepldlpqiierlhglsaftlhsyspg
einrvasclrklgvpplrtwrhrarsvrakllsqggraaicgrylfnwavrtklkltpip
aasqldlsgwfvagysggdiyhslsrar

Sequence, based on observed residues (ATOM records):

>d3skaa_ e.8.1.4 (A:) automated matches {Hepatitis C virus [TaxId: 420174]}
smsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhir
svwedlledtetpidttimaksevfcvqrkparlivfpdlgvrvcekmalydvvstlpqa
vmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiyqccdl
apearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkataacra
aklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeydlelits
cssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlwarmil
mthffsillaqeqlgkaldcqiygacysiepldlpqiierlhglsaftlhsyspgeinrv
asclrklgvpplrtwrhrarsvrakllsqggraaicgrylfnwavrtklkltpipaasql
dlsgwfvagysggdiyhslsrar

Timeline for d3skaa_:

• d3skaa_ first appeared in SCOPe 2.03
  
• d3skaa_ appears in SCOPe 2.04
  
• d3skaa_ appears in SCOPe 2.06
  
• d3skaa_ appears in the current release, SCOPe 2.08