SCOPe 2.06: Domain d3ob7a_: 3ob7 A:

Lineage for d3ob7a_ (3ob7 A:)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
   contains large mixed beta-sheet

4. Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (2 families)
   automatically mapped to Pfam PF00303

5. Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (4 proteins)

6. Protein Thymidylate synthase [55833] (7 species)

7. Species Human (Homo sapiens) [TaxId:9606] [55840] (26 PDB entries)

8. Domain d3ob7a_: 3ob7 A: [214286]
   automated match to d2aaza_
   complexed with gsh, po4

Details for d3ob7a_

PDB Entry: 3ob7, 2.75 Å

PDB Description: human thymidylate synthase r163k with cys 195 covalently modified by glutathione

PDB Compounds: (A:) Thymidylate synthase

SCOPe Domain Sequences for d3ob7a_:

Sequence; same for both SEQRES and ATOM records:

>d3ob7a_ d.117.1.1 (A:) Thymidylate synthase {Human (Homo sapiens) [TaxId: 9606]}
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgae
yrdmesdysgqgvdqlqkvidtiktnpddrriimcawnprdlplmalppchalcqfyvvn
selscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiepl
kiqlqreprpfpklrilrkvekiddfkaedfqiegynphpt

Timeline for d3ob7a_:

• d3ob7a_ first appeared in SCOPe 2.03
  
• d3ob7a_ appears in SCOPe 2.05
  
• d3ob7a_ appears in SCOPe 2.07
  
• d3ob7a_ appears in the current release, SCOPe 2.08