SCOPe 2.08: Domain d2opma_: 2opm A:

Lineage for d2opma_ (2opm A:)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.128: Terpenoid synthases [48575] (1 superfamily)
   multihelical; core: 8 helices (C-J) are arranged in 2 parallel layers

4. Superfamily a.128.1: Terpenoid synthases [48576] (6 families)
   duplication: two metal-binding sites are related by a pseudo dyad that also relates helices C-F to helices G-J

5. Family a.128.1.1: Isoprenyl diphosphate synthases [48577] (4 proteins)

6. Protein automated matches [190489] (5 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187688] (85 PDB entries)

8. Domain d2opma_: 2opm A: [205349]
   automated match to d2f89f_
   complexed with mg, ni9, po4

Details for d2opma_

PDB Entry: 2opm, 2.4 Å

PDB Description: Human Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-461

PDB Compounds: (A:) Farnesyl pyrophosphate synthetase (FPP synthetase) (FPS) (Farnesyl diphosphate synthetase) [Includes: Dimethylallyltranstransferase (EC 2.5.1.1); Geranyltranstransferase (EC 2.5.1.10)]

SCOPe Domain Sequences for d2opma_:

Sequence, based on SEQRES records:

>d2opma_ a.128.1.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ekqdfvqhfsqivrvltedemghpeigdaiarlkevleynaiggkynrgltvvvafrelv
eprkqdadslqrawtvgwcvellqafflvaddimdssltrrgqicwyqkpgvgldainda
nlleaciyrllklycreqpyylnlielflqssyqteigqtldlltapqgnvdlvrftekr
yksivkyktafysfylpiaaamymagidgekehanakkillemgeffqiqddyldlfgdp
svtgkigtdiqdnkcswlvvqclqratpeqyqilkenygqkeaekvarvkalyeeldlpa
vflqyeedsyshimalieqyaaplppavflglarkiyk

Sequence, based on observed residues (ATOM records):

>d2opma_ a.128.1.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ekqdfvqhfsqivrvltedehpeigdaiarlkevleynaiggkynrgltvvvafrelvep
rkqdadslqrawtvgwcvellqafflvaddimdssltrrgqicwyqkpgvgldaindanl
leaciyrllklycreqpyylnlielflqssyqteigqtldlltapqgnvdlvrftekryk
sivkyktafysfylpiaaamymagidgekehanakkillemgeffqiqddyldlfgdpsv
tgkigtdiqdnkcswlvvqclqratpeqyqilkenygqkeaekvarvkalyeeldlpavf
lqyeedsyshimalieqyaaplppavflglarkiyk

Timeline for d2opma_:

• d2opma_ first appeared in SCOPe 2.03
  
• d2opma_ appears in SCOPe 2.07