SCOPe 2.05: Domain d2onba_: 2onb A:

Lineage for d2onba_ (2onb A:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
   contains large mixed beta-sheet

4. Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (2 families)
   automatically mapped to Pfam PF00303

5. Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (4 proteins)

6. Protein Thymidylate synthase [55833] (7 species)

7. Species Human (Homo sapiens) [TaxId:9606] [55840] (24 PDB entries)

8. Domain d2onba_: 2onb A: [205332]
   automated match to d1hw3a_
   complexed with 7pa, edo, so4

Details for d2onba_

PDB Entry: 2onb, 2.7 Å

PDB Description: human thymidylate synthase at low salt conditions with pdpa bound

PDB Compounds: (A:) Thymidylate synthetase

SCOPe Domain Sequences for d2onba_:

Sequence, based on SEQRES records:

>d2onba_ d.117.1.1 (A:) Thymidylate synthase {Human (Homo sapiens) [TaxId: 9606]}
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgae
yrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvvn
selscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiepl
kiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikme

Sequence, based on observed residues (ATOM records):

>d2onba_ d.117.1.1 (A:) Thymidylate synthase {Human (Homo sapiens) [TaxId: 9606]}
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstnakelsskgvkgdlgpvygfqwrhfgaeyrdmesdysgqgvdqlqrvid
tiktnpddrriimcawnprdlplmalppchalcqfyvvnselscqlyqrsgdmglgvpfn
iasyalltymiahitglkpgdfihtlgdahiylnhieplkiqlqreprpfpklrilrkve
kiddfkaedfqiegynphptikme

Timeline for d2onba_:

• d2onba_ first appeared in SCOPe 2.03
  
• d2onba_ appears in SCOPe 2.04
  
• d2onba_ appears in SCOPe 2.06
  
• d2onba_ appears in the current release, SCOPe 2.08