SCOPe 2.07: Domain d2dxsa_: 2dxs A:

Lineage for d2dxsa_ (2dxs A:)

1. Root: SCOPe 2.07

2. Class e: Multi-domain proteins (alpha and beta) [56572] (71 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (8 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.4: RNA-dependent RNA-polymerase [56694] (3 proteins)

6. Protein automated matches [190260] (25 species)
   not a true protein

7. Species Hepatitis C virus [TaxId:11103] [187048] (44 PDB entries)

8. Domain d2dxsa_: 2dxs A: [204047]
   automated match to d3vqsd_
   protein/RNA complex; complexed with jtp

Details for d2dxsa_

PDB Entry: 2dxs, 2.2 Å

PDB Description: crystal structure of hcv ns5b rna polymerase complexed with a tetracyclic inhibitor

PDB Compounds: (A:) Genome polyprotein

SCOPe Domain Sequences for d2dxsa_:

Sequence, based on SEQRES records:

>d2dxsa_ e.8.1.4 (A:) automated matches {Hepatitis C virus [TaxId: 11103]}
smsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
svwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiy
qccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkas
aacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspg
einrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpip
aasq

Sequence, based on observed residues (ATOM records):

>d2dxsa_ e.8.1.4 (A:) automated matches {Hepatitis C virus [TaxId: 11103]}
smsytwtgalitpcvyattsrsaglrqkkvtfdrlqvlddhyrdvlkemkakastvkakl
lsveeackltpphsakskfgygakdvrnlsskavnhihsvwkdlledtvtpidttimakn
evfcvgrkparlivfpdlgvrvcekmalydvvstlpqvvmgssygfqyspgqrveflvnt
wkskknpmgfsydtrcfdstvtendirveesiyqccdlapearqaikslterlyiggplt
nskgqncgyrrcrasgvlttscgntltcylkasaacraaklqdctmlvngddlvvicesa
gtqedaaslrvfteamtrysappgdppqpeydlelitscssnvsvahdasgkrvyyltrd
pttplaraawetarhtpvnswlgniimyaptlwarmilmthffsillaqeqlekaldcqi
ygacysiepldlpqiierlhglsafslhsyspgeinrvasclrklgvpplrvwrhrarsv
rarllsqggraatcgkylfnwavktklkltpipaasq

Timeline for d2dxsa_:

• d2dxsa_ first appeared in SCOPe 2.03
  
• d2dxsa_ appears in SCOPe 2.06
  
• d2dxsa_ appears in the current release, SCOPe 2.08