SCOPe 2.05: Domain d4kaib_: 4kai B:

Lineage for d4kaib_ (4kai B:)

1. Root: SCOPe 2.05

2. Class e: Multi-domain proteins (alpha and beta) [56572] (68 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (7 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.4: RNA-dependent RNA-polymerase [56694] (3 proteins)

6. Protein Viral RNA polymerase [56695] (17 species)

7. Species Hepatitis c virus isolate [TaxId:420174] [188905] (18 PDB entries)

8. Domain d4kaib_: 4kai B: [197111]
   automated match to d3gnwb_
   protein/RNA complex; complexed with 1pv

Details for d4kaib_

PDB Entry: 4kai, 2.3 Å

PDB Description: hcv ns5b gt1b n316 with gsk5852a

PDB Compounds: (B:) HCV Polymerase

SCOPe Domain Sequences for d4kaib_:

Sequence, based on SEQRES records:

>d4kaib_ e.8.1.4 (B:) Viral RNA polymerase {Hepatitis c virus isolate [TaxId: 420174]}
smsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsagqrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskygygakdvrnlssravnhih
svwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiy
qccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkas
aacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspg
einrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpip
aasrldlsgwfvagysggdiyhsl

Sequence, based on observed residues (ATOM records):

>d4kaib_ e.8.1.4 (B:) Viral RNA polymerase {Hepatitis c virus isolate [TaxId: 420174]}
smsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsagqrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskygygakdvrnlssravnhih
svwkdlledtvtpidttimaknevfcvqprkparlivfpdlgvrvcekmalydvvstlpq
vvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiyqccd
lapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkasaacr
aaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydlelit
scssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlwarmi
lmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspgeinr
vasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpipwfva
gysggdiyhsl

Timeline for d4kaib_:

• d4kaib_ first appeared in SCOPe 2.02
  
• d4kaib_ appears in SCOPe 2.04
  
• d4kaib_ appears in SCOPe 2.06
  
• d4kaib_ appears in the current release, SCOPe 2.08