SCOPe 2.05: Domain d1fo3a_: 1fo3 A:

Lineage for d1fo3a_ (1fo3 A:)

1. Root: SCOPe 2.05

2. Class a: All alpha proteins [46456] (286 folds)

3. Fold a.102: alpha/alpha toroid [48207] (6 superfamilies)
   multihelical; up to seven alpha-hairpins are arranged in closed circular array; there may be sequence similarities between different superfamilies

4. Superfamily a.102.2: Seven-hairpin glycosidases [48225] (1 family)
   automatically mapped to Pfam PF01532

5. Family a.102.2.1: Class I alpha-1;2-mannosidase, catalytic domain [48226] (1 protein)

6. Protein Class I alpha-1;2-mannosidase, catalytic domain [48227] (5 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48229] (4 PDB entries)

8. Domain d1fo3a_: 1fo3 A: [18845]
   complexed with ca, kif, so4

Details for d1fo3a_

PDB Entry: 1fo3, 1.75 Å

PDB Description: crystal structure of human class i alpha1,2-mannosidase in complex with kifunensine

PDB Compounds: (A:) alpha1,2-mannosidase

SCOPe Domain Sequences for d1fo3a_:

Sequence, based on SEQRES records:

>d1fo3a_ a.102.2.1 (A:) Class I alpha-1;2-mannosidase, catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
qgpvhlnyrqkgvidvflhawkgyrkfawghdelkpvsrsfsewfglgltlidaldtmwi
lglrkefeearkwvskklhfekdvdvnlfestirilggllsayhlsgdslflrkaedfgn
rlmpafrtpskipysdvnigtgvahpprwtsdstvaevtsiqlefrelsrltgdkkfqea
vekvtqhihglsgkkdglvpmfinthsglfthlgvftlgaradsyyeyllkqwiqggkqe
tqlledyveaiegvrthllrhsepskltfvgelahgrfsakmdhlvcflpgtlalgvyhg
lpashmelaqelmetcyqmnrqmetglspeivhfnlypqpgrrdvevkpadrhnllrpet
veslfylyrvtgdrkyqdwgweilqsfsrftrvpsggyssinnvqdpqkpeprdkmesff
lgetlkylfllfsddpnllsldayvfnteahplpiwt

Sequence, based on observed residues (ATOM records):

>d1fo3a_ a.102.2.1 (A:) Class I alpha-1;2-mannosidase, catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
qgpvhlnyrqkgvidvflhawkgyrkfawghdelkpvsrsfsewfglgltlidaldtmwi
lglrkefeearkwvskklhfekdvdvnlfestirilggllsayhlsgdslflrkaedfgn
rlmpafrtpskipysdvnigtgvahpprsdstvaevtsiqlefrelsrltgdkkfqeave
kvtqhihglsgkkdglvpmfinthsglfthlgvftlgaradsyyeyllkqwiqggkqetq
lledyveaiegvrthllrhsepskltfvgelahgrfsakmdhlvcflpgtlalgvyhglp
ashmelaqelmetcyqmnrqmetglspeivhfnlypqpgrrdvevkpadrhnllrpetve
slfylyrvtgdrkyqdwgweilqsfsrftrvpsggyssinnvqdpqkpeprdkmesfflg
etlkylfllfsddpnllsldayvfnteahplpiwt

Timeline for d1fo3a_:

• d1fo3a_ first appeared (with stable ids) in SCOP 1.55
  
• d1fo3a_ appears in SCOPe 2.04
  
• d1fo3a_ appears in SCOPe 2.06
  
• d1fo3a_ appears in the current release, SCOPe 2.08