SCOPe 2.07: Domain d3uphb_: 3uph B:

Lineage for d3uphb_ (3uph B:)

1. Root: SCOPe 2.07

2. Class e: Multi-domain proteins (alpha and beta) [56572] (71 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (8 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.4: RNA-dependent RNA-polymerase [56694] (3 proteins)

6. Protein automated matches [190260] (25 species)
   not a true protein

7. Species Hepatitis C virus [TaxId:420174] [189885] (5 PDB entries)

8. Domain d3uphb_: 3uph B: [186371]
   automated match to d1nb4a_
   complexed with 0c1, po4

Details for d3uphb_

PDB Entry: 3uph, 2 Å

PDB Description: Synthesis of novel 4,5-dihydrofurano indoles and their evaluation as HCV NS5B polymerase inhibitors

PDB Compounds: (B:) RNA-directed RNA polymerase

SCOPe Domain Sequences for d3uphb_:

Sequence, based on SEQRES records:

>d3uphb_ e.8.1.4 (B:) automated matches {Hepatitis C virus [TaxId: 420174]}
smsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhir
svwedlledtetpidttimaksevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiy
qccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkat
aacraaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlw
armilmthffsillaqeqlgkaldcqiygacysiepldlpqiierlhglsaftlhsyspg
einrvasclrklgvpplrtwrhrarsvrakllsqggraaicgrylfnwavrtklkltpip
aasqldlsgwfvagysggdiyhs

Sequence, based on observed residues (ATOM records):

>d3uphb_ e.8.1.4 (B:) automated matches {Hepatitis C virus [TaxId: 420174]}
smsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhir
svwedlledtetpidttimaksevfcvqrkparlivfpdlgvrvcekmalydvvstlpqa
vmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiyqccdl
apearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkataacra
aklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeydlelits
cssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlwarmil
mthffsillaqeqlgkaldcqiygacysiepldlpqiierlhglsaftlhsyspgeinrv
asclrklgvpplrtwrhrarsvrakllsqggraaicgrylfnwavrtklkltpipaasql
dlsgwfvagysggdiyhs

Timeline for d3uphb_:

• d3uphb_ first appeared in SCOPe 2.01
  
• d3uphb_ appears in SCOPe 2.06
  
• d3uphb_ appears in the current release, SCOPe 2.08