SCOPe 2.02: Domain d3rhxb_: 3rhx B:

Lineage for d3rhxb_ (3rhx B:)

1. Root: SCOPe 2.02

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Fibroblast growth factor receptor 1 [56158] (1 species)
   PTK group; FGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56159] (9 PDB entries)

8. Domain d3rhxb_: 3rhx B: [184971]
   automated match to d1agwb_
   complexed with 3rh, edo, so4

Details for d3rhxb_

PDB Entry: 3rhx, 2.01 Å

PDB Description: Crystal structure of the catalytic domain of FGFR1 kinase in complex with ARQ 069

PDB Compounds: (B:) Basic fibroblast growth factor receptor 1

SCOPe Domain Sequences for d3rhxb_:

Sequence, based on SEQRES records:

>d3rhxb_ d.144.1.7 (B:) Fibroblast growth factor receptor 1 {Human (Homo sapiens) [TaxId: 9606]}
seyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkmlksda
tekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrppg
leysynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvmkia
dfglardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgvllweiftlggsp
ypgvpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldrival
t

Sequence, based on observed residues (ATOM records):

>d3rhxb_ d.144.1.7 (B:) Fibroblast growth factor receptor 1 {Human (Homo sapiens) [TaxId: 9606]}
seyelpedprwelprdrlvlgkplgegafgqvvlaeaiglpnrvtkvavkmlksdatekd
lsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrqlsskdl
vscayqvargmeylaskkcihrdlaarnvlvtednvmkiadfgladyykkttngrlpvkw
mapealfdriythqsdvwsfgvllweiftlggspypgvpveelfkllkeghrmdkpsnct
nelymmmrdcwhavpsqrptfkqlvedldrivalt

Timeline for d3rhxb_:

• d3rhxb_ first appeared in SCOPe 2.01
  
• d3rhxb_ appears in SCOPe 2.03
  
• d3rhxb_ appears in the current release, SCOPe 2.08