SCOPe 2.01: Domain d3r4pb_: 3r4p B:

Lineage for d3r4pb_ (3r4p B:)

1. Root: SCOPe 2.01

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.122: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55873] (1 superfamily)
   8-stranded mixed beta-sheet; 2 layers: alpha/beta

4. Superfamily d.122.1: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55874] (4 families)

5. Family d.122.1.1: Heat shock protein 90, HSP90, N-terminal domain [55875] (2 proteins)

6. Protein HSP90 [55876] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [55878] (53 PDB entries)
   Uniprot P08238 10-220 # HSP 90-beta isoform ! Uniprot P07900 16-223

8. Domain d3r4pb_: 3r4p B: [184807]
   automated match to d1osfa_
   complexed with fu7, po4

Details for d3r4pb_

PDB Entry: 3r4p, 1.7 Å

PDB Description: Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide

PDB Compounds: (B:) Heat shock protein HSP 90-alpha

SCOPe Domain Sequences for d3r4pb_:

Sequence; same for both SEQRES and ATOM records:

>d3r4pb_ d.122.1.1 (B:) HSP90 {Human (Homo sapiens) [TaxId: 9606]}
mdqpmeeeevetfafqaeiaqlmsliintfysnkeiflrelisnssdaldkiryesltdp
skldsgkelhinlipnkqdrtltivdtgigmtkadlinnlgtiaksgtkafmealqagad
ismigqfgvgfysaylvaekvtvitkhnddeqyawessaggsftvrtdtgepmgrgtkvi
lhlkedqteyleerrikeivkkhsqfigypitlfvekelehh

Timeline for d3r4pb_:

• d3r4pb_ is new in SCOPe 2.01-stable
  
• d3r4pb_ appears in SCOPe 2.02
  
• d3r4pb_ appears in the current release, SCOPe 2.08, called d3r4pb1