SCOPe 2.04: Domain d3qgha_: 3qgh A:

Lineage for d3qgha_ (3qgh A:)

1. Root: SCOPe 2.04

2. Class e: Multi-domain proteins (alpha and beta) [56572] (68 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (7 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.4: RNA-dependent RNA-polymerase [56694] (3 proteins)

6. Protein Viral RNA polymerase [56695] (17 species)

7. Species Hepatitis c virus subtype 1a [TaxId:31646] [189928] (4 PDB entries)

8. Domain d3qgha_: 3qgh A: [184375]
   automated match to d1nb4a_
   protein/RNA complex; complexed with 63f, po4

Details for d3qgha_

PDB Entry: 3qgh, 2.14 Å

PDB Description: Crystal structure of the hepatitis C virus NS5B RNA-dependent RNA polymerase genotype 1a complex with N-cyclopropyl-6-[(3R)-3-{[4-(trifluoromethoxy)benzyl]carbamoyl}-4-{[4-(trifluoromethoxy)phenyl]sulfonyl}piperazin-1-yl]pyridazine-3-carboxamide

PDB Compounds: (A:) RNA-directed RNA polymerase

SCOPe Domain Sequences for d3qgha_:

Sequence, based on SEQRES records:

>d3qgha_ e.8.1.4 (A:) Viral RNA polymerase {Hepatitis c virus subtype 1a [TaxId: 31646]}
smsyswtgalvtpcaaeeqklpinalsnsllrhhnlvysttsrsacqrqkkvtfdrlqvl
dshyqdvlkevkaaaskvkanllsveeacsltpphsakskfgygakdvrcharkavahin
svwkdlledsvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
klplavmgssygfqyspgqrveflvqawkskktpmgfsydtrcfdstvtesdirteeaiy
qccdldpqarvaikslterlyvggpltnsrgencgyrrcrasgvlttscgntltcyikar
aacraaglqdctmlvcgddlvvicesagvqedaaslrafteamtrysappgdppqpeydl
elitscssnvsvahdgagkrvyyltrdpttplaraawetarhtpvnswlgniimfaptlw
armilmthffsvliardqleqalnceiygacysiepldlppiiqrlhglsafslhsyspg
einrvaaclrklgvpplrawrhrarsvrarllsrggraaicgkylfnwavrtklkltpia
aagrldlsgwftagysggdiy

Sequence, based on observed residues (ATOM records):

>d3qgha_ e.8.1.4 (A:) Viral RNA polymerase {Hepatitis c virus subtype 1a [TaxId: 31646]}
smsyswtgalvtpcaaeeqklpinalsnsllrhhnlvysttsrsacqrqkkvtfdrlqvl
dshyqdvlkevkaaaskvkanllsveeacsltpphsakskfgygakdvrcharkavahin
svwkdlledsvtpidttimaknevfcvqpekrkparlivfpdlgvrvcekmalydvvskl
plavmgssygfqyspgqrveflvqawkskktpmgfsydtrcfdstvtesdirteeaiyqc
cdldpqarvaikslterlyvggpltnsrgencgyrrcrasgvlttscgntltcyikaraa
craaglqdctmlvcgddlvvicesagvqedaaslrafteamtrysappgdppqpeydlel
itscssnvsvahdgagkrvyyltrdpttplaraawetarhtpvnswlgniimfaptlwar
milmthffsvliardqleqalnceiygacysiepldlppiiqrlhglsafslhsyspgei
nrvaaclrklgvpplrawrhrarsvrarllsrggraaicgkylfnwavrtklkltpiaaa
grldlsgwftagysggdiy

Timeline for d3qgha_:

• d3qgha_ first appeared in SCOPe 2.01
  
• d3qgha_ appears in SCOPe 2.03
  
• d3qgha_ appears in SCOPe 2.05
  
• d3qgha_ appears in the current release, SCOPe 2.08