SCOPe 2.04: Domain d3h5ua_: 3h5u A:

Lineage for d3h5ua_ (3h5u A:)

1. Root: SCOPe 2.04

2. Class e: Multi-domain proteins (alpha and beta) [56572] (68 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (7 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.4: RNA-dependent RNA-polymerase [56694] (3 proteins)

6. Protein Viral RNA polymerase [56695] (17 species)

7. Species Hepatitis C virus [TaxId:11103] [56697] (72 PDB entries)

8. Domain d3h5ua_: 3h5u A: [177203]
   automated match to d1nb4a_
   complexed with h5u

Details for d3h5ua_

PDB Entry: 3h5u, 1.95 Å

PDB Description: Hepatitis C virus polymerase NS5B with saccharin inhibitor 1

PDB Compounds: (A:) RNA-directed RNA polymerase

SCOPe Domain Sequences for d3h5ua_:

Sequence, based on SEQRES records:

>d3h5ua_ e.8.1.4 (A:) Viral RNA polymerase {Hepatitis C virus [TaxId: 11103]}
hmsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
svwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiy
qccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkas
aacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspg
einrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpip
aasrldlsgwfvagysggdiyhs

Sequence, based on observed residues (ATOM records):

>d3h5ua_ e.8.1.4 (A:) Viral RNA polymerase {Hepatitis C virus [TaxId: 11103]}
hmsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
svwkdlledtvtpidttimaknevfcvqgrkparlivfpdlgvrvcekmalydvvstlpq
vvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiyqccd
lapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkasaacr
aaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydlelit
scssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlwarmi
lmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspgeinr
vasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpipaasr
ldlsgwfvagysggdiyhs

Timeline for d3h5ua_:

• d3h5ua_ first appeared in SCOPe 2.01
  
• d3h5ua_ appears in SCOPe 2.03
  
• d3h5ua_ appears in SCOPe 2.05
  
• d3h5ua_ appears in the current release, SCOPe 2.08, called d3h5ua1