SCOPe 2.04: Domain d3gnwb_: 3gnw B:

Lineage for d3gnwb_ (3gnw B:)

1. Root: SCOPe 2.04

2. Class e: Multi-domain proteins (alpha and beta) [56572] (68 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (7 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.4: RNA-dependent RNA-polymerase [56694] (3 proteins)

6. Protein Viral RNA polymerase [56695] (17 species)

7. Species Hepatitis c virus isolate [TaxId:420174] [188905] (16 PDB entries)

8. Domain d3gnwb_: 3gnw B: [176786]
   automated match to d1nb4a_
   protein/RNA complex; complexed with cl, xnc

Details for d3gnwb_

PDB Entry: 3gnw, 2.39 Å

PDB Description: hcv ns5b polymerase in complex with 1,5 benzodiazepine inhibitor 4c

PDB Compounds: (B:) RNA-directed RNA polymerase

SCOPe Domain Sequences for d3gnwb_:

Sequence, based on SEQRES records:

>d3gnwb_ e.8.1.4 (B:) Viral RNA polymerase {Hepatitis c virus isolate [TaxId: 420174]}
smsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhir
svwedlledtetpidttimaksevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiy
qccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkat
aacraaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsyspg
einrvasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklkltpip
aasqldlsgwfvagysggdiyhslsrarprl

Sequence, based on observed residues (ATOM records):

>d3gnwb_ e.8.1.4 (B:) Viral RNA polymerase {Hepatitis c virus isolate [TaxId: 420174]}
smsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhir
svwedlledtetpidttimaksevfcvqpgrkparlivfpdlgvrvcekmalydvvstlp
qavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiyqcc
dlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkataac
raaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeydleli
tscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlwarm
ilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsyspgein
rvasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklkltpipaas
qldlsgwfvagysggdiyhslsrarprl

Timeline for d3gnwb_:

• d3gnwb_ first appeared in SCOPe 2.01
  
• d3gnwb_ appears in SCOPe 2.03
  
• d3gnwb_ appears in SCOPe 2.05
  
• d3gnwb_ appears in the current release, SCOPe 2.08, called d3gnwb1