SCOP 1.75: Domain d2op9b1: 2op9 B:2-301

Lineage for d2op9b1 (2op9 B:2-301)

1. Root: SCOP 1.75

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (4 families)

5. Family b.47.1.4: Viral cysteine protease of trypsin fold [50603] (3 proteins)

6. Protein Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) [74979] (3 species)
   contains an extra alpha-helical domain

7. Species SARS coronavirus [TaxId:227859] [89349] (20 PDB entries)

8. Domain d2op9b1: 2op9 B:2-301 [148962]
   automatically matched to d1q2wb_
   complexed with wr1

Details for d2op9b1

PDB Entry: 2op9, 1.8 Å

PDB Description: substrate specificity profiling and identification of a new class of inhibitor for the major protease of the sars coronavirus

PDB Compounds: (B:) Replicase polyprotein 1ab (pp1ab, ORF1AB) 3C-like proteinase (3CL-PRO, 3CLp)

SCOP Domain Sequences for d2op9b1:

Sequence, based on SEQRES records:

>d2op9b1 b.47.1.4 (B:2-301) Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) {SARS coronavirus [TaxId: 227859]}
gfrkmafpsgkvegcmvqvtcgtttlnglwlddtvycprhvictaedmlnpnyedllirk
snhsflvqagnvqlrvighsmqncllrlkvdtsnpktpkykfvriqpgqtfsvlacyngs
psgvyqcamrpnhtikgsflngscgsvgfnidydcvsfcymhhmelptgvhagtdlegkf
ygpfvdrqtaqaagtdttitlnvlawlyaavingdrwflnrftttlndfnlvamkynyep
ltqdhvdilgplsaqtgiavldmcaalkellqngmngrtilgstiledeftpfdvvrqcs

Sequence, based on observed residues (ATOM records):

>d2op9b1 b.47.1.4 (B:2-301) Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) {SARS coronavirus [TaxId: 227859]}
gfrkmafpsgkvegcmvqvtcgtttlnglwlddtvycprhvictedmlnpnyedllirks
nhsflvqagnvqlrvighsmqncllrlkvdtsnpktpkykfvriqpgqtfsvlacyngsp
sgvyqcamrpnhtikgsflngscgsvgfnidycvsfcymhhmelptgvhagtdlegkfyg
pfvdrqtaqaagtdttitlnvlawlyaavingdrwflnrftttlndfnlvamkynyeplt
qdhvdilgplsaqtgiavldmcaalkellqngmngrtilgstiledeftpfdvvrqcs

Timeline for d2op9b1:

• d2op9b1 is new in SCOP 1.75
  
• d2op9b1 is called d2op9b_ in SCOPe 2.01
  
• d2op9b1 appears in the current release, SCOPe 2.08, called d2op9b_