SCOPe 2.07: Domain d2ijna2: 2ijn A:3-564

Lineage for d2ijna2 (2ijn A:3-564)

1. Root: SCOPe 2.07

2. Class e: Multi-domain proteins (alpha and beta) [56572] (71 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (8 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.4: RNA-dependent RNA-polymerase [56694] (3 proteins)

6. Protein automated matches [190260] (25 species)
   not a true protein

7. Species Hepatitis C virus subtype 1b [TaxId:31647] [187148] (6 PDB entries)

8. Domain d2ijna2: 2ijn A:3-564 [137478]
   Other proteins in same PDB: d2ijna3, d2ijnb3
   automated match to d1c2pb_
   complexed with 221

Details for d2ijna2

PDB Entry: 2ijn, 2.2 Å

PDB Description: Isothiazoles as active-site inhibitors of HCV NS5B polymerase

PDB Compounds: (A:) RNA polymerase NS5B

SCOPe Domain Sequences for d2ijna2:

Sequence, based on SEQRES records:

>d2ijna2 e.8.1.4 (A:3-564) automated matches {Hepatitis C virus subtype 1b [TaxId: 31647]}
sytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvldd
hyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhihsv
wkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvstl
pqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiyqc
cdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkasaa
craaklqdctmlvngddlvvicesagvqedaaslrafteamtrysappgdppqpeydlel
itscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlwar
milmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspgei
nrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpipaa
sqldlsgwfvagysggdiyhsl

Sequence, based on observed residues (ATOM records):

>d2ijna2 e.8.1.4 (A:3-564) automated matches {Hepatitis C virus subtype 1b [TaxId: 31647]}
sytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvldd
hyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhihsv
wkdlledtvtpidttimaknevfcvqrkparlivfpdlgvrvcekmalydvvstlpqvvm
gssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiyqccdlap
earqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkasaacraak
lqdctmlvngddlvvicesagvqedaaslrafteamtrysappgdppqpeydlelitscs
snvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlwarmilmt
hffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspgeinrvas
clrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpipaasqldl
sgwfvagysggdiyhsl

Timeline for d2ijna2:

• d2ijna2 first appeared in SCOP 1.73, called d2ijna1
  
• d2ijna2 appears in SCOPe 2.06
  
• d2ijna2 appears in the current release, SCOPe 2.08