SCOPe 2.02: Domain d2ezta2: 2ezt A:9-182

Lineage for d2ezta2 (2ezt A:9-182)

1. Root: SCOPe 2.02

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

4. Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (8 families)
   there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
   two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules

5. Family c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module [88724] (8 proteins)
   the N-terminal, Pyr module is separated from the C-terminal, PP module by an alpha/beta domain of Rossmann-like topology

6. Protein Pyruvate oxidase [88729] (2 species)

7. Species Lactobacillus plantarum [TaxId:1590] [88730] (7 PDB entries)

8. Domain d2ezta2: 2ezt A:9-182 [132634]
   Other proteins in same PDB: d2ezta1, d2ezta3, d2eztb1, d2eztb3
   automatically matched to d1powa2
   complexed with fad, mg, na, po4, pyr, tdm

Details for d2ezta2

PDB Entry: 2ezt, 2.29 Å

PDB Description: pyruvate oxidase variant f479w in complex with reaction intermediate 2-hydroxyethyl-thiamin diphosphate

PDB Compounds: (A:) Pyruvate oxidase

SCOPe Domain Sequences for d2ezta2:

Sequence; same for both SEQRES and ATOM records:

>d2ezta2 c.36.1.5 (A:9-182) Pyruvate oxidase {Lactobacillus plantarum [TaxId: 1590]}
tnilagaavikvleawgvdhlygipggsinsimdalsaerdrihyiqvrheevgamaaaa
dakltgkigvcfgsagpggthlmnglydaredhvpvlaligqfgttgmnmdtfqemnenp
iyadvadynvtavnaatlphvideairrayahqgvavvqipvdlpwqqipaedw

Timeline for d2ezta2:

• d2ezta2 first appeared in SCOP 1.73
  
• d2ezta2 appears in SCOPe 2.01
  
• d2ezta2 appears in SCOPe 2.03
  
• d2ezta2 appears in the current release, SCOPe 2.08