SCOPe 2.08: Domain d2dw5a3: 2dw5 A:294-663

Lineage for d2dw5a3 (2dw5 A:294-663)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.126: Pentein, beta/alpha-propeller [55908] (1 superfamily)
   duplication: composed of 5 alpha-beta(2)-alpha-beta units arranged around pseudo fivefold axis

4. Superfamily d.126.1: Pentein [55909] (8 families)

5. Family d.126.1.5: Peptidylarginine deiminase Pad4, catalytic C-terminal domain [111152] (1 protein)
   # functionally related to the amidinotransferase, similar active sites
   automatically mapped to Pfam PF03068

6. Protein Peptidylarginine deiminase Pad4, catalytic C-terminal domain [111153] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [111154] (17 PDB entries)
   Uniprot Q9UM07

8. Domain d2dw5a3: 2dw5 A:294-663 [131807]
   Other proteins in same PDB: d2dw5a1, d2dw5a2
   automated match to d2dw5a3
   complexed with bfb, ca, so4

Details for d2dw5a3

PDB Entry: 2dw5, 2.3 Å

PDB Description: Crystal structure of human peptidylarginine deiminase 4 in complex with N-alpha-benzoyl-N5-(2-fluoro-1-iminoethyl)-L-ornithine amide

PDB Compounds: (A:) Protein-arginine deiminase type-4

SCOPe Domain Sequences for d2dw5a3:

Sequence, based on SEQRES records:

>d2dw5a3 d.126.1.5 (A:294-663) Peptidylarginine deiminase Pad4, catalytic C-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
apwimtpntqppqevyacsifenedflksvttlamkakcklticpeeenmddqwmqdeme
igyiqaphktlpvvfdsprnrglkefpikrvmgpdfgyvtrgpqtggisgldsfgnlevs
ppvtvrgkeyplgrilfgdscypsndsrqmhqalqdflsaqqvqapvklysdwlsvghvd
eflsfvpapdrkgfrlllasprscyklfqeqqneghgeallfegikkkkqqkiknilsnk
tlrehnsfvercidwnrellkrelglaesdiidipqlfklkefskaeaffpnmvnmlvlg
khlgipkpfgpvingrccleekvcslleplglqctfindfftyhirhgevhcgtnvrrkp
fsfkwwnmvp

Sequence, based on observed residues (ATOM records):

>d2dw5a3 d.126.1.5 (A:294-663) Peptidylarginine deiminase Pad4, catalytic C-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
apwimtpntqppqevyacsenedflksvttlamkakcklticpeeenmddqwmqdemeig
yiqaphktlpvvfdsprnrglkefpikrvmgpdfgyvtrgpqtggisgldsfgnlevspp
vtvrgkeyplgrilfgdscypsndsrqmhqalqdflsaqqvqapvklysdwlsvghvdef
lsfvpapdrkgfrlllasprscyklfqeqqneghgeallfegikkkkqqkiknilsnktl
rehnsfvercidwnrellkrelglaesdiidipqlfklkefskaeaffpnmvnmlvlgkh
lgipkpfgpvingrccleekvcslleplglqctfindfftyhirhgevhcgtnvrrkpfs
fkwwnmvp

Timeline for d2dw5a3:

• d2dw5a3 first appeared in SCOP 1.73
  
• d2dw5a3 appears in SCOPe 2.07