SCOPe 2.04: Domain d2brka_: 2brk A:

Lineage for d2brka_ (2brk A:)

1. Root: SCOPe 2.04

2. Class e: Multi-domain proteins (alpha and beta) [56572] (68 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (7 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.4: RNA-dependent RNA-polymerase [56694] (3 proteins)

6. Protein Viral RNA polymerase [56695] (17 species)

7. Species Hepatitis C virus [TaxId:11103] [56697] (72 PDB entries)

8. Domain d2brka_: 2brk A: [129001]
   automated match to d1gx5a_
   protein/RNA complex; complexed with cmf, mn

Details for d2brka_

PDB Entry: 2brk, 2.3 Å

PDB Description: crystal structure of hepatitis c virus polymerase in complex with an allosteric inhibitor (compound 1)

PDB Compounds: (A:) RNA-directed RNA polymerase

SCOPe Domain Sequences for d2brka_:

Sequence, based on SEQRES records:

>d2brka_ e.8.1.4 (A:) Viral RNA polymerase {Hepatitis C virus [TaxId: 11103]}
smsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
svwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiy
qccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkas
aacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspg
einrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavk

Sequence, based on observed residues (ATOM records):

>d2brka_ e.8.1.4 (A:) Viral RNA polymerase {Hepatitis C virus [TaxId: 11103]}
smsytwtgalitpcaaeesklmvyattsrsaglrqkkvtfdrlqvlddhyrdvlkemkak
astvkakllsveeackltpphsakskfgygakdvrnlsskavnhihsvwkdlledtvtpi
dttimaknevfcvgrkparlivfpdlgvrvcekmalydvvstlpqvvmgssygfqyspgq
rveflvntwkskknpmgfsydtrcfdstvtendirveesiyqccdlapearqaikslter
lyiggpltnskgqncgyrrcrasgvlttscgntltcylkasaacraaklqdctmlvngdd
lvvicesagtqedaaslrvfteamtrysappgdppqpeydlelitscssnvsvahdasgk
rvyyltrdpttplaraawetarhtpvnswlgniimyaptlwarmilmthffsillaqeql
ekaldcqiygacysiepldlpqiierlhglsafslhsyspgeinrvasclrklgvpplrv
wrhrarsvrarllsqggraatcgkylfnwavk

Timeline for d2brka_:

• d2brka_ first appeared in SCOP 1.73, called d2brka1
  
• d2brka_ appears in SCOPe 2.03
  
• d2brka_ appears in SCOPe 2.05
  
• d2brka_ appears in the current release, SCOPe 2.08