SCOPe 2.05: Domain d1r1ja_: 1r1j A:

Lineage for d1r1ja_ (1r1j A:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.92: Zincin-like [55485] (2 superfamilies)
   contains mixed beta sheet with connection over free side of the sheet

4. Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain [55486] (18 families)

5. Family d.92.1.4: Neutral endopeptidase (neprilysin) [55502] (2 proteins)

6. Protein Neutral endopeptidase (neprilysin) [55503] (1 species)
   contains thermolysin-like catalytic domain (residues 419-749)
   the N-terminal half of the structure is multihelical

7. Species Human (Homo sapiens) [TaxId:9606] [55504] (6 PDB entries)
   Uniprot P08473 54-749

8. Domain d1r1ja_: 1r1j A: [104758]
   complexed with nag, oir, zn

Details for d1r1ja_

PDB Entry: 1r1j, 2.35 Å

PDB Description: structural analysis of neprilysin with various specific and potent inhibitors

PDB Compounds: (A:) Neprilysin

SCOPe Domain Sequences for d1r1ja_:

Sequence; same for both SEQRES and ATOM records:

>d1r1ja_ d.92.1.4 (A:) Neutral endopeptidase (neprilysin) {Human (Homo sapiens) [TaxId: 9606]}
gickssdciksaarliqnmdattepctdffkyacggwlkrnvipetssrygnfdilrdel
evvlkdvlqepktedivavqkakalyrscinesaidsrggepllkllpdiygwpvatenw
eqkygaswtaekaiaqlnskygkkvlinlfvgtddknsvnhvihidqprlglpsrdyyec
tgiykeactayvdfmisvarlirqeerlpidenqlalemnkvmelekeianatakpedrn
dpmllynkmtlaqiqnnfsleingkpfswlnftneimstvnisitneedvvvyapeyltk
lkpiltkysardlqnlmswrfimdlvsslsrtykesrnafrkalygttsetatwrrcany
vngnmenavgrlyveaafageskhvvedliaqirevfiqtlddltwmdaetkkraeekal
aikerigypddivsndnklnneylelnykedeyfeniiqnlkfsqskqlkklrekvdkde
wisgaavvnafyssgrnqivfpagilqppffsaqqsnslnyggigmvigheithgfddng
rnfnkdgdlvdwwtqqsasnfkeqsqcmvyqygnfswdlaggqhlngintlgeniadngg
lgqayrayqnyikkngeekllpgldlnhkqlfflnfaqvwcgtyrpeyavnsiktdvhsp
gnfriigtlqnsaefseafhcrknsymnpekkcrvw

Timeline for d1r1ja_:

• d1r1ja_ first appeared in SCOP 1.69
  
• d1r1ja_ appears in SCOPe 2.04
  
• d1r1ja_ appears in SCOPe 2.06
  
• d1r1ja_ appears in the current release, SCOPe 2.08