PDB entry 7vp9

View 7vp9 on RCSB PDB site
Description: Crystal structure of human ClpP in complex with ZG111
Class: hydrolase
Keywords: mitochondrial protease, HYDROLASE
Deposited on 2021-10-15, released 2022-06-08
The last revision prior to the SCOPe 2.08 freeze date was dated 2022-08-10, with a file datestamp of 2022-08-05.
Experiment type: XRAY
Resolution: 2.55 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ATP-dependent Clp protease proteolytic subunit, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7vp9a_
  • Chain 'B':
    Compound: ATP-dependent Clp protease proteolytic subunit, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7vp9b_
  • Chain 'C':
    Compound: ATP-dependent Clp protease proteolytic subunit, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7vp9c_
  • Chain 'D':
    Compound: ATP-dependent Clp protease proteolytic subunit, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7vp9d_
  • Chain 'E':
    Compound: ATP-dependent Clp protease proteolytic subunit, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7vp9e_
  • Chain 'F':
    Compound: ATP-dependent Clp protease proteolytic subunit, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7vp9f_
  • Chain 'G':
    Compound: ATP-dependent Clp protease proteolytic subunit, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7vp9g_
  • Chain 'H':
    Compound: ATP-dependent Clp protease proteolytic subunit, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7vp9h_
  • Chain 'I':
    Compound: ATP-dependent Clp protease proteolytic subunit, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7vp9i_
  • Chain 'J':
    Compound: ATP-dependent Clp protease proteolytic subunit, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7vp9j_
  • Chain 'K':
    Compound: ATP-dependent Clp protease proteolytic subunit, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7vp9k_
  • Chain 'L':
    Compound: ATP-dependent Clp protease proteolytic subunit, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7vp9l_
  • Chain 'M':
    Compound: ATP-dependent Clp protease proteolytic subunit, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7vp9m_
  • Chain 'N':
    Compound: ATP-dependent Clp protease proteolytic subunit, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: CLPP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7vp9n_
  • Heterogens: 7SR, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7vp9A (A:)
plipivveqtgrgeraydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpih
myinspggvvtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrim
ihqpsggargqatdiaiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaq
efgildkvlvhppqdgedeptlvqkepveaapaaepvpast

    Sequence, based on observed residues (ATOM records): (download) 
    >7vp9A (A:)
lipivydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpihmyinspggvvt
aglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrimihqpiqaeeim
klkkqlyniyakhtkqslqviesamerdrymspmeaqefgildkvlvhpp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7vp9B (B:)
plipivveqtgrgeraydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpih
myinspggvvtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrim
ihqpsggargqatdiaiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaq
efgildkvlvhppqdgedeptlvqkepveaapaaepvpast

    Sequence, based on observed residues (ATOM records): (download) 
    >7vp9B (B:)
lipivydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpihmyinspggvvt
aglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrimihqpiqaeeim
klkkqlyniyakhtkqslqviesamerdrymspmeaqefgildkvlvhpp

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >7vp9C (C:)
plipivveqtgrgeraydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpih
myinspggvvtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrim
ihqpsggargqatdiaiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaq
efgildkvlvhppqdgedeptlvqkepveaapaaepvpast

    Sequence, based on observed residues (ATOM records): (download) 
    >7vp9C (C:)
ipiydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpihmyinspggvvtag
laiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrimihqpiqaeeimkl
kkqlyniyakhtkqslqviesamerdrymspmeaqefgildkvlvhpp

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >7vp9D (D:)
plipivveqtgrgeraydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpih
myinspggvvtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrim
ihqpsggargqatdiaiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaq
efgildkvlvhppqdgedeptlvqkepveaapaaepvpast

    Sequence, based on observed residues (ATOM records): (download) 
    >7vp9D (D:)
lipivaydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpihmyinspggvv
taglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrimihqpiqaeei
mklkkqlyniyakhtkqslqviesamerdrymspmeaqefgildkvlvhp

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >7vp9E (E:)
plipivveqtgrgeraydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpih
myinspggvvtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrim
ihqpsggargqatdiaiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaq
efgildkvlvhppqdgedeptlvqkepveaapaaepvpast

    Sequence, based on observed residues (ATOM records): (download) 
    >7vp9E (E:)
lipivvydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpihmyinspggvv
taglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrimihqpiqaeei
mklkkqlyniyakhtkqslqviesamerdrymspmeaqefgildkvlvhpp

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >7vp9F (F:)
plipivveqtgrgeraydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpih
myinspggvvtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrim
ihqpsggargqatdiaiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaq
efgildkvlvhppqdgedeptlvqkepveaapaaepvpast

    Sequence, based on observed residues (ATOM records): (download) 
    >7vp9F (F:)
plipivydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpihmyinspggvv
taglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrimihqpiqaeei
mklkkqlyniyakhtkqslqviesamerdrymspmeaqefgildkvlvhpp

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >7vp9G (G:)
plipivveqtgrgeraydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpih
myinspggvvtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrim
ihqpsggargqatdiaiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaq
efgildkvlvhppqdgedeptlvqkepveaapaaepvpast

    Sequence, based on observed residues (ATOM records): (download) 
    >7vp9G (G:)
lipivydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpihmyinspggvvt
aglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrimihqpiqaeeim
klkkqlyniyakhtkqslqviesamerdrymspmeaqefgildkvlvhpp

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >7vp9H (H:)
plipivveqtgrgeraydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpih
myinspggvvtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrim
ihqpsggargqatdiaiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaq
efgildkvlvhppqdgedeptlvqkepveaapaaepvpast

    Sequence, based on observed residues (ATOM records): (download) 
    >7vp9H (H:)
lipivveqtgrgeraydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpihm
yinspggvvtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrimi
hqpiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaqefgildkvlvhpp

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >7vp9I (I:)
plipivveqtgrgeraydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpih
myinspggvvtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrim
ihqpsggargqatdiaiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaq
efgildkvlvhppqdgedeptlvqkepveaapaaepvpast

    Sequence, based on observed residues (ATOM records): (download) 
    >7vp9I (I:)
plipivvergeraydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpihmyi
nspggvvtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrimihq
piqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaqefgildkvlvhpp

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >7vp9J (J:)
plipivveqtgrgeraydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpih
myinspggvvtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrim
ihqpsggargqatdiaiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaq
efgildkvlvhppqdgedeptlvqkepveaapaaepvpast

    Sequence, based on observed residues (ATOM records): (download) 
    >7vp9J (J:)
plipivveqteraydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpihmyi
nspggvvtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrimihq
piqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaqefgildkvlvhpp

  • Chain 'K':
    Sequence, based on SEQRES records: (download) 
    >7vp9K (K:)
plipivveqtgrgeraydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpih
myinspggvvtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrim
ihqpsggargqatdiaiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaq
efgildkvlvhppqdgedeptlvqkepveaapaaepvpast

    Sequence, based on observed residues (ATOM records): (download) 
    >7vp9K (K:)
plipivveeraydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpihmyins
pggvvtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrimihqpi
qaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaqefgildkvlvhpp

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >7vp9L (L:)
plipivveqtgrgeraydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpih
myinspggvvtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrim
ihqpsggargqatdiaiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaq
efgildkvlvhppqdgedeptlvqkepveaapaaepvpast

    Sequence, based on observed residues (ATOM records): (download) 
    >7vp9L (L:)
plipivveqtgeraydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpihmy
inspggvvtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrimih
qpiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaqefgildkvlvhpp

  • Chain 'M':
    Sequence, based on SEQRES records: (download) 
    >7vp9M (M:)
plipivveqtgrgeraydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpih
myinspggvvtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrim
ihqpsggargqatdiaiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaq
efgildkvlvhppqdgedeptlvqkepveaapaaepvpast

    Sequence, based on observed residues (ATOM records): (download) 
    >7vp9M (M:)
lipivveqtgrgeraydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpihm
yinspggvvtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrimi
hqpiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaqefgildkvlvhp

  • Chain 'N':
    Sequence, based on SEQRES records: (download) 
    >7vp9N (N:)
plipivveqtgrgeraydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpih
myinspggvvtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrim
ihqpsggargqatdiaiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaq
efgildkvlvhppqdgedeptlvqkepveaapaaepvpast

    Sequence, based on observed residues (ATOM records): (download) 
    >7vp9N (N:)
lipivveqtgrgeraydiysrllrerivcvmgpiddsvaslviaqllflqsesnkkpihm
yinspggvvtaglaiydtmqyilnpictwcvgqaasmgslllaagtpgmrhslpnsrimi
hqpiqaeeimklkkqlyniyakhtkqslqviesamerdrymspmeaqefgildkvlvhp