PDB entry 7s49

View 7s49 on RCSB PDB site
Description: Crystal Structure of Inhibitor-bound Galactokinase
Class: Transferase/Inhibitor
Keywords: GALK, galactokinase, Galactose, Inhibitor, disulfide, SUGAR BINDING PROTEIN, Transferase-Inhibitor complex
Deposited on 2021-09-08, released 2021-09-29
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-10-06, with a file datestamp of 2021-10-01.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Galactokinase
    Species: Homo sapiens [TaxId:9606]
    Gene: GALK1, GALK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51570 (0-391)
      • engineered mutation (251-252)
    Domains in SCOPe 2.08: d7s49a1, d7s49a2
  • Chain 'B':
    Compound: Galactokinase
    Species: Homo sapiens [TaxId:9606]
    Gene: GALK1, GALK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51570 (0-391)
      • engineered mutation (251-252)
    Domains in SCOPe 2.08: d7s49b1, d7s49b2
  • Heterogens: 4QI, GLA, PO4, NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7s49A (A:)
maalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvlpmalelm
tvlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgviqyypaa
plpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqaehsfagm
pcgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhslasseypvrr
rqceevaralgaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaaalrrgdy
rafgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctvtlleasa
aphamrhiqehyggtatfylsqaadgakvlcl

    Sequence, based on observed residues (ATOM records): (download) 
    >7s49A (A:)
aalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvlpmalelmt
vlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgviqyypaap
lpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqaehsfagmp
cgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhslasseypvrrr
qceevaralgaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaaalrrgdyr
afgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctvtlleasaa
phamrhiqehyggtatfylsqaadgakvlcl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7s49B (B:)
maalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvlpmalelm
tvlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgviqyypaa
plpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqaehsfagm
pcgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhslasseypvrr
rqceevaralgaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaaalrrgdy
rafgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctvtlleasa
aphamrhiqehyggtatfylsqaadgakvlcl

    Sequence, based on observed residues (ATOM records): (download) 
    >7s49B (B:)
aalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvlpmalelmt
vlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgviqyypaap
lpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqaehsfagmp
cgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhslasseypvrrr
qceevaralgaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaaalrrgdyr
afgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctvtlleasaa
phamrhiqehyggtatfylsqaadgakvlcl