PDB entry 7req

View 7req on RCSB PDB site
Description: methylmalonyl-coa mutase, 2-carboxypropyl-coa inhibitor complex
Class: isomerase
Keywords: isomerase, mutase, intramolecular transferase
Deposited on 1998-09-10, released 1998-09-16
The last revision prior to the SCOPe 2.08 freeze date was dated 2012-10-24, with a file datestamp of 2012-10-19.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.195
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: protein (methylmalonyl-coa mutase)
    Species: Propionibacterium freudenreichii [TaxId:1752]
    Gene: mutB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7reqa1, d7reqa2
  • Chain 'B':
    Compound: protein (methylmalonyl-coa mutase)
    Species: Propionibacterium freudenreichii [TaxId:1752]
    Gene: MUTA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11652 (Start-636)
      • see remark 999 (201)
      • see remark 999 (328-329)
    Domains in SCOPe 2.08: d7reqb1, d7reqb2
  • Chain 'C':
    Compound: protein (methylmalonyl-coa mutase)
    Species: Propionibacterium freudenreichii [TaxId:1752]
    Gene: mutB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7reqc1, d7reqc2
  • Chain 'D':
    Compound: protein (methylmalonyl-coa mutase)
    Species: Propionibacterium freudenreichii [TaxId:1752]
    Gene: MUTA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11652 (Start-636)
      • see remark 999 (201)
      • see remark 999 (328-329)
    Domains in SCOPe 2.08: d7reqd1, d7reqd2
  • Heterogens: 2CP, B12, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7reqA (A:)
stlprfdsvdlgnapvpadaarrfeelaakagtgeawetaeqipvgtlfnedvykdmdwl
dtyagippfvhgpyatmyafrpwtirqyagfstakesnafyrrnlaagqkglsvafdlpt
hrgydsdnprvagdvgmagvaidsiydmrelfagipldqmsvsmtmngavlpilalyvvt
aeeqgvkpeqlagtiqndilkefmvrntyiyppqpsmriiseifaytsanmpkwnsisis
gyhmqeagatadiemaytladgvdyiragesvglnvdqfaprlsffwgigmnffmevakl
raarmlwaklvhqfgpknpksmslrthsqtsgwsltaqdvynnvvrtcieamaatqghtq
slhtnsldeaialptdfsariarntqlflqqesgttrvidpwsgsayveeltwdlarkaw
ghiqevekvggmakaiekgipkmrieeaaartqaridsgrqpligvnkyrleheppldvl
kvdnstvlaeqkaklvklraerdpekvkaaldkitwaagnpddkdpdrnllklcidagra
matvgemsdalekvfgrytaqirtisgvyskevkntpeveearelveefeqaegrrpril
lakmgqdghdrgqkviatayadlgfdvdvgplfqtpeetarqaveadvhvvgvsslaggh
ltlvpalrkeldklgrpdilitvggvipeqdfdelrkdgaveiytpgtvipesaislvkk
lraslda

    Sequence, based on observed residues (ATOM records): (download) 
    >7reqA (A:)
lprfdsvdlgnapvpadaarrfeelaakagtgeawetaeqipvgtlfnedvykdmdwldt
yagippfvhgpyatmyafrpwtirqyagfstakesnafyrrnlaagqkglsvafdlpthr
gydsdnprvagdvgmagvaidsiydmrelfagipldqmsvsmtmngavlpilalyvvtae
eqgvkpeqlagtiqndilkefmvrntyiyppqpsmriiseifaytsanmpkwnsisisgy
hmqeagatadiemaytladgvdyiragesvglnvdqfaprlsffwgigmnffmevaklra
armlwaklvhqfgpknpksmslrthsqtsgwsltaqdvynnvvrtcieamaatqghtqsl
htnsldeaialptdfsariarntqlflqqesgttrvidpwsgsayveeltwdlarkawgh
iqevekvggmakaiekgipkmrieeaaartqaridsgrqpligvnkyrleheppldvlkv
dnstvlaeqkaklvklraerdpekvkaaldkitwaagnpddkdpdrnllklcidagrama
tvgemsdalekvfgrytaqirtisgvyskevkntpeveearelveefeqaegrrprilla
kmgqdghdrgqkviatayadlgfdvdvgplfqtpeetarqaveadvhvvgvsslagghlt
lvpalrkeldklgrpdilitvggvipeqdfdelrkdgaveiytpgtvipesaislvkklr
aslda

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7reqB (B:)
sstdqgtnpadtddltpttlslagdfpkateeqwerevekvlnrgrppekqltfaeclkr
ltvhtvdgidivpmyrpkdapkklgypgvapftrgttvrngdmdawdvralhedpdekft
rkaileglergvtslllrvdpdaiapehldevlsdvllemtkvevfsrydqgaaaealvs
vyersdkpakdlalnlgldpigfaalqgtepdltvlgdwvrrlakfspdsravtidaniy
hnagagdvaelawalatgaeyvralveqgftateafdtinfrvtathdqfltiarlralr
eawarigevfgvdedkrgarqnaitswreltredpyvnilrgsiatfsasvggaesittl
pftqalglpeddfplriarntgivlaeevnigrvndpaggsyyvesltrsladaawkefq
eveklggmskavmtehvtkvldacnaerakrlanrkqpitavsefpmigarsietkpfpa
aparkglawhrdsevfeqlmdrstsvserpkvflaclgtrrdfggregfsspvwhiagid
tpqveggttaeiveafkksgaqvadlcssakvyaqqglevakalkaagakalylsgafke
fgddaaeaeklidgrlfmgmdvvdtlsstldilgvak

    Sequence, based on observed residues (ATOM records): (download) 
    >7reqB (B:)
ltpttlslagdfpkateeqwerevekvlnrgrppekqltfaeclkrltvhtvdgidivpm
yrpkdapkklgypgvapftrgttvrngdmdawdvralhedpdekftrkaileglergvts
lllrvdpdaiapehldevlsdvllemtkvevfsrydqgaaaealvsvyersdkpakdlal
nlgldpigfaalqgtepdltvlgdwvrrlakfspdsravtidaniyhnagagdvaelawa
latgaeyvralveqgftateafdtinfrvtathdqfltiarlralreawarigevfgvde
dkrgarqnaitswreltredpyvnilrgsiatfsasvggaesittlpftqalglpeddfp
lriarntgivlaeevnigrvndpaggsyyvesltrsladaawkefqeveklggmskavmt
ehvtkvldacnaerakrlanrkqpitavsefpmigarsietkpfpaaparkglawhrdse
vfeqlmdrstsvserpkvflaclgtrrdfggregfsspvwhiagidtpqveggttaeive
afkksgaqvadlcssakvyaqqglevakalkaagakalylsgafkefgddaaeaeklidg
rlfmgmdvvdtlsstldilgvak

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >7reqC (C:)
stlprfdsvdlgnapvpadaarrfeelaakagtgeawetaeqipvgtlfnedvykdmdwl
dtyagippfvhgpyatmyafrpwtirqyagfstakesnafyrrnlaagqkglsvafdlpt
hrgydsdnprvagdvgmagvaidsiydmrelfagipldqmsvsmtmngavlpilalyvvt
aeeqgvkpeqlagtiqndilkefmvrntyiyppqpsmriiseifaytsanmpkwnsisis
gyhmqeagatadiemaytladgvdyiragesvglnvdqfaprlsffwgigmnffmevakl
raarmlwaklvhqfgpknpksmslrthsqtsgwsltaqdvynnvvrtcieamaatqghtq
slhtnsldeaialptdfsariarntqlflqqesgttrvidpwsgsayveeltwdlarkaw
ghiqevekvggmakaiekgipkmrieeaaartqaridsgrqpligvnkyrleheppldvl
kvdnstvlaeqkaklvklraerdpekvkaaldkitwaagnpddkdpdrnllklcidagra
matvgemsdalekvfgrytaqirtisgvyskevkntpeveearelveefeqaegrrpril
lakmgqdghdrgqkviatayadlgfdvdvgplfqtpeetarqaveadvhvvgvsslaggh
ltlvpalrkeldklgrpdilitvggvipeqdfdelrkdgaveiytpgtvipesaislvkk
lraslda

    Sequence, based on observed residues (ATOM records): (download) 
    >7reqC (C:)
lprfdsvdlgnapvpadaarrfeelaakagtgeawetaeqipvgtlfnedvykdmdwldt
yagippfvhgpyatmyafrpwtirqyagfstakesnafyrrnlaagqkglsvafdlpthr
gydsdnprvagdvgmagvaidsiydmrelfagipldqmsvsmtmngavlpilalyvvtae
eqgvkpeqlagtiqndilkefmvrntyiyppqpsmriiseifaytsanmpkwnsisisgy
hmqeagatadiemaytladgvdyiragesvglnvdqfaprlsffwgigmnffmevaklra
armlwaklvhqfgpknpksmslrthsqtsgwsltaqdvynnvvrtcieamaatqghtqsl
htnsldeaialptdfsariarntqlflqqesgttrvidpwsgsayveeltwdlarkawgh
iqevekvggmakaiekgipkmrieeaaartqaridsgrqpligvnkyrleheppldvlkv
dnstvlaeqkaklvklraerdpekvkaaldkitwaagnpddkdpdrnllklcidagrama
tvgemsdalekvfgrytaqirtisgvyskevkntpeveearelveefeqaegrrprilla
kmgqdghdrgqkviatayadlgfdvdvgplfqtpeetarqaveadvhvvgvsslagghlt
lvpalrkeldklgrpdilitvggvipeqdfdelrkdgaveiytpgtvipesaislvkklr
aslda

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >7reqD (D:)
sstdqgtnpadtddltpttlslagdfpkateeqwerevekvlnrgrppekqltfaeclkr
ltvhtvdgidivpmyrpkdapkklgypgvapftrgttvrngdmdawdvralhedpdekft
rkaileglergvtslllrvdpdaiapehldevlsdvllemtkvevfsrydqgaaaealvs
vyersdkpakdlalnlgldpigfaalqgtepdltvlgdwvrrlakfspdsravtidaniy
hnagagdvaelawalatgaeyvralveqgftateafdtinfrvtathdqfltiarlralr
eawarigevfgvdedkrgarqnaitswreltredpyvnilrgsiatfsasvggaesittl
pftqalglpeddfplriarntgivlaeevnigrvndpaggsyyvesltrsladaawkefq
eveklggmskavmtehvtkvldacnaerakrlanrkqpitavsefpmigarsietkpfpa
aparkglawhrdsevfeqlmdrstsvserpkvflaclgtrrdfggregfsspvwhiagid
tpqveggttaeiveafkksgaqvadlcssakvyaqqglevakalkaagakalylsgafke
fgddaaeaeklidgrlfmgmdvvdtlsstldilgvak

    Sequence, based on observed residues (ATOM records): (download) 
    >7reqD (D:)
ltpttlslagdfpkateeqwerevekvlnrgrppekqltfaeclkrltvhtvdgidivpm
yrpkdapkklgypgvapftrgttvrngdmdawdvralhedpdekftrkaileglergvts
lllrvdpdaiapehldevlsdvllemtkvevfsrydqgaaaealvsvyersdkpakdlal
nlgldpigfaalqgtepdltvlgdwvrrlakfspdsravtidaniyhnagagdvaelawa
latgaeyvralveqgftateafdtinfrvtathdqfltiarlralreawarigevfgvde
dkrgarqnaitswreltredpyvnilrgsiatfsasvggaesittlpftqalglpeddfp
lriarntgivlaeevnigrvndpaggsyyvesltrsladaawkefqeveklggmskavmt
ehvtkvldacnaerakrlanrkqpitavsefpmigarsietkpfpaaparkglawhrdse
vfeqlmdrstsvserpkvflaclgtrrdfggregfsspvwhiagidtpqveggttaeive
afkksgaqvadlcssakvyaqqglevakalkaagakalylsgafkefgddaaeaeklidg
rlfmgmdvvdtlsstldilgvak