PDB entry 7rb0

View 7rb0 on RCSB PDB site
Description: Cryo-EM structure of SARS-CoV-2 NSP15 NendoU at pH 7.5
Class: viral protein
Keywords: nsp15, sars-cov-2, nendoU, coronavirus, covid-19, VIRAL PROTEIN
Deposited on 2021-07-05, released 2021-07-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-07-14, with a file datestamp of 2021-07-09.
Experiment type: EM
Resolution: 2.98 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Uridylate-specific endoribonuclease
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: rep, 1a-1b
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTD1 (3-348)
      • expression tag (0-2)
    Domains in SCOPe 2.08: d7rb0a1, d7rb0a2, d7rb0a3
  • Chain 'B':
    Compound: Uridylate-specific endoribonuclease
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: rep, 1a-1b
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTD1 (3-348)
      • expression tag (0-2)
    Domains in SCOPe 2.08: d7rb0b1, d7rb0b2, d7rb0b3
  • Chain 'C':
    Compound: Uridylate-specific endoribonuclease
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: rep, 1a-1b
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTD1 (3-348)
      • expression tag (0-2)
    Domains in SCOPe 2.08: d7rb0c1, d7rb0c2, d7rb0c3
  • Chain 'D':
    Compound: Uridylate-specific endoribonuclease
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: rep, 1a-1b
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTD1 (3-348)
      • expression tag (0-2)
    Domains in SCOPe 2.08: d7rb0d1, d7rb0d2, d7rb0d3
  • Chain 'E':
    Compound: Uridylate-specific endoribonuclease
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: rep, 1a-1b
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTD1 (3-348)
      • expression tag (0-2)
    Domains in SCOPe 2.08: d7rb0e1, d7rb0e2, d7rb0e3
  • Chain 'F':
    Compound: Uridylate-specific endoribonuclease
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: rep, 1a-1b
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTD1 (3-348)
      • expression tag (0-2)
    Domains in SCOPe 2.08: d7rb0f1, d7rb0f2, d7rb0f3

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7rb0A (A:)
gamslenvafnvvnkghfdgqqgevpvsiinntvytkvdgvdvelfenkttlpvnvafel
wakrnikpvpevkilnnlgvdiaantviwdykrdapahistigvcsmtdiakkptetica
pltvffdgrvdgqvdlfrnarngvlitegsvkglqpsvgpkqaslngvtligeavktqfn
yykkvdgvvqqlpetyftqsrnlqefkprsqmeidflelamdefieryklegyafehivy
gdfshsqlgglhlliglakrfkespfeledfipmdstvknyfitdaqtgsskcvcsvidl
llddfveiiksqdlsvvskvvkvtidyteisfmlwckdghvetfypklq

    Sequence, based on observed residues (ATOM records): (download) 
    >7rb0A (A:)
amslenvafnvvnkghfdgqqgevpvsiinntvytkvdgvdvelfenkttlpvnvafelw
akrnikpvpevkilnnlgvdiaantviwdykrdapahistigvcsmtdiakkpteticap
ltvffdgrvdgqvdlfrnarngvlitegsvkglqpsvgpkqaslngvtligeavktqfny
ykkvdgvvqqlpetyftqsrnlqefkprsqmeidflelamdefieryklegyafehivyg
dfshsqlgglhlliglakrfkespfeledfipmdstvknyfitdaqtgsskcvcsvidll
lddfveiiksqdlsvvskvvkvtidyteisfmlwckdghvetfypkl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7rb0B (B:)
gamslenvafnvvnkghfdgqqgevpvsiinntvytkvdgvdvelfenkttlpvnvafel
wakrnikpvpevkilnnlgvdiaantviwdykrdapahistigvcsmtdiakkptetica
pltvffdgrvdgqvdlfrnarngvlitegsvkglqpsvgpkqaslngvtligeavktqfn
yykkvdgvvqqlpetyftqsrnlqefkprsqmeidflelamdefieryklegyafehivy
gdfshsqlgglhlliglakrfkespfeledfipmdstvknyfitdaqtgsskcvcsvidl
llddfveiiksqdlsvvskvvkvtidyteisfmlwckdghvetfypklq

    Sequence, based on observed residues (ATOM records): (download) 
    >7rb0B (B:)
amslenvafnvvnkghfdgqqgevpvsiinntvytkvdgvdvelfenkttlpvnvafelw
akrnikpvpevkilnnlgvdiaantviwdykrdapahistigvcsmtdiakkpteticap
ltvffdgrvdgqvdlfrnarngvlitegsvkglqpsvgpkqaslngvtligeavktqfny
ykkvdgvvqqlpetyftqsrnlqefkprsqmeidflelamdefieryklegyafehivyg
dfshsqlgglhlliglakrfkespfeledfipmdstvknyfitdaqtgsskcvcsvidll
lddfveiiksqdlsvvskvvkvtidyteisfmlwckdghvetfypkl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >7rb0C (C:)
gamslenvafnvvnkghfdgqqgevpvsiinntvytkvdgvdvelfenkttlpvnvafel
wakrnikpvpevkilnnlgvdiaantviwdykrdapahistigvcsmtdiakkptetica
pltvffdgrvdgqvdlfrnarngvlitegsvkglqpsvgpkqaslngvtligeavktqfn
yykkvdgvvqqlpetyftqsrnlqefkprsqmeidflelamdefieryklegyafehivy
gdfshsqlgglhlliglakrfkespfeledfipmdstvknyfitdaqtgsskcvcsvidl
llddfveiiksqdlsvvskvvkvtidyteisfmlwckdghvetfypklq

    Sequence, based on observed residues (ATOM records): (download) 
    >7rb0C (C:)
amslenvafnvvnkghfdgqqgevpvsiinntvytkvdgvdvelfenkttlpvnvafelw
akrnikpvpevkilnnlgvdiaantviwdykrdapahistigvcsmtdiakkpteticap
ltvffdgrvdgqvdlfrnarngvlitegsvkglqpsvgpkqaslngvtligeavktqfny
ykkvdgvvqqlpetyftqsrnlqefkprsqmeidflelamdefieryklegyafehivyg
dfshsqlgglhlliglakrfkespfeledfipmdstvknyfitdaqtgsskcvcsvidll
lddfveiiksqdlsvvskvvkvtidyteisfmlwckdghvetfypkl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >7rb0D (D:)
gamslenvafnvvnkghfdgqqgevpvsiinntvytkvdgvdvelfenkttlpvnvafel
wakrnikpvpevkilnnlgvdiaantviwdykrdapahistigvcsmtdiakkptetica
pltvffdgrvdgqvdlfrnarngvlitegsvkglqpsvgpkqaslngvtligeavktqfn
yykkvdgvvqqlpetyftqsrnlqefkprsqmeidflelamdefieryklegyafehivy
gdfshsqlgglhlliglakrfkespfeledfipmdstvknyfitdaqtgsskcvcsvidl
llddfveiiksqdlsvvskvvkvtidyteisfmlwckdghvetfypklq

    Sequence, based on observed residues (ATOM records): (download) 
    >7rb0D (D:)
amslenvafnvvnkghfdgqqgevpvsiinntvytkvdgvdvelfenkttlpvnvafelw
akrnikpvpevkilnnlgvdiaantviwdykrdapahistigvcsmtdiakkpteticap
ltvffdgrvdgqvdlfrnarngvlitegsvkglqpsvgpkqaslngvtligeavktqfny
ykkvdgvvqqlpetyftqsrnlqefkprsqmeidflelamdefieryklegyafehivyg
dfshsqlgglhlliglakrfkespfeledfipmdstvknyfitdaqtgsskcvcsvidll
lddfveiiksqdlsvvskvvkvtidyteisfmlwckdghvetfypkl

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >7rb0E (E:)
gamslenvafnvvnkghfdgqqgevpvsiinntvytkvdgvdvelfenkttlpvnvafel
wakrnikpvpevkilnnlgvdiaantviwdykrdapahistigvcsmtdiakkptetica
pltvffdgrvdgqvdlfrnarngvlitegsvkglqpsvgpkqaslngvtligeavktqfn
yykkvdgvvqqlpetyftqsrnlqefkprsqmeidflelamdefieryklegyafehivy
gdfshsqlgglhlliglakrfkespfeledfipmdstvknyfitdaqtgsskcvcsvidl
llddfveiiksqdlsvvskvvkvtidyteisfmlwckdghvetfypklq

    Sequence, based on observed residues (ATOM records): (download) 
    >7rb0E (E:)
amslenvafnvvnkghfdgqqgevpvsiinntvytkvdgvdvelfenkttlpvnvafelw
akrnikpvpevkilnnlgvdiaantviwdykrdapahistigvcsmtdiakkpteticap
ltvffdgrvdgqvdlfrnarngvlitegsvkglqpsvgpkqaslngvtligeavktqfny
ykkvdgvvqqlpetyftqsrnlqefkprsqmeidflelamdefieryklegyafehivyg
dfshsqlgglhlliglakrfkespfeledfipmdstvknyfitdaqtgsskcvcsvidll
lddfveiiksqdlsvvskvvkvtidyteisfmlwckdghvetfypkl

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >7rb0F (F:)
gamslenvafnvvnkghfdgqqgevpvsiinntvytkvdgvdvelfenkttlpvnvafel
wakrnikpvpevkilnnlgvdiaantviwdykrdapahistigvcsmtdiakkptetica
pltvffdgrvdgqvdlfrnarngvlitegsvkglqpsvgpkqaslngvtligeavktqfn
yykkvdgvvqqlpetyftqsrnlqefkprsqmeidflelamdefieryklegyafehivy
gdfshsqlgglhlliglakrfkespfeledfipmdstvknyfitdaqtgsskcvcsvidl
llddfveiiksqdlsvvskvvkvtidyteisfmlwckdghvetfypklq

    Sequence, based on observed residues (ATOM records): (download) 
    >7rb0F (F:)
amslenvafnvvnkghfdgqqgevpvsiinntvytkvdgvdvelfenkttlpvnvafelw
akrnikpvpevkilnnlgvdiaantviwdykrdapahistigvcsmtdiakkpteticap
ltvffdgrvdgqvdlfrnarngvlitegsvkglqpsvgpkqaslngvtligeavktqfny
ykkvdgvvqqlpetyftqsrnlqefkprsqmeidflelamdefieryklegyafehivyg
dfshsqlgglhlliglakrfkespfeledfipmdstvknyfitdaqtgsskcvcsvidll
lddfveiiksqdlsvvskvvkvtidyteisfmlwckdghvetfypkl