PDB entry 7ls6

View 7ls6 on RCSB PDB site
Description: Cryo-EM structure of Pre-15S proteasome core particle assembly intermediate purified from Pre3-1 proteasome mutant (G34D)
Class: hydrolase
Keywords: core particle, complex, assembly intermediate, HYDROLASE
Deposited on 2021-02-17, released 2021-04-14
The last revision prior to the SCOPe 2.07 freeze date was dated 2021-04-28, with a file datestamp of 2021-04-23.
Experiment type: EM
Resolution: 3.17 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Proteasome subunit alpha type-1
    Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) [TaxId:559292]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d7ls6a_
  • Chain 'B':
    Compound: Proteasome subunit alpha type-2
    Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) [TaxId:559292]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d7ls6b_
  • Chain 'C':
    Compound: Proteasome subunit alpha type-3
    Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) [TaxId:559292]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d7ls6c_
  • Chain 'D':
    Compound: Proteasome subunit alpha type-4
    Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) [TaxId:559292]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d7ls6d_
  • Chain 'E':
    Compound: Proteasome subunit alpha type-5
    Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) [TaxId:559292]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d7ls6e_
  • Chain 'F':
    Compound: Proteasome subunit alpha type-6
    Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) [TaxId:559292]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d7ls6f_
  • Chain 'G':
    Compound: Proteasome subunit alpha type-7
    Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) [TaxId:559292]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d7ls6g_
  • Chain 'H':
    Compound: Proteasome maturation factor UMP1
    Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) [TaxId:559292]
    Database cross-references and differences (RAF-indexed):
  • Chain 'I':
    Compound: Proteasome subunit beta type-2
    Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) [TaxId:559292]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d7ls6i_
  • Chain 'J':
    Compound: Proteasome subunit beta type-3
    Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) [TaxId:559292]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d7ls6j_
  • Chain 'K':
    Compound: Proteasome subunit beta type-4
    Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) [TaxId:559292]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d7ls6k_
  • Chain 'L':
    Compound: Proteasome subunit beta type-5
    Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) [TaxId:559292]
    Database cross-references and differences (RAF-indexed):
  • Chain 'M':
    Compound: Proteasome subunit beta type-6
    Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) [TaxId:559292]
    Database cross-references and differences (RAF-indexed):
  • Chain 'O':
    Compound: Proteasome chaperone 1
    Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) [TaxId:559292]
    Database cross-references and differences (RAF-indexed):
  • Chain 'P':
    Compound: Proteasome assembly chaperone 2
    Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) [TaxId:559292]
    Database cross-references and differences (RAF-indexed):

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7ls6A (A:)
msgaaaasaagydrhitifspegrlyqveyafkatnqtninslavrgkdctvvisqkkvp
dklldpttvsyifcisrtigmvvngpipdarnaalrakaeaaefrykygydmpcdvlakr
manlsqiytqraymrplgviltfvsvdeelgpsiyktdpagyyvgykatatgpkqqeitt
nlenhfkkskidhineeswekvvefaithmidalgtefskndlevgvatkdkfftlsaen
ieerlvaiaeqd

    Sequence, based on observed residues (ATOM records): (download) 
    >7ls6A (A:)
asaagydrhitifspegrlyqveyafkatnqtninslavrgkdctvvisqkkvpdklldp
ttvsyifcisrtigmvvngpipdarnaalrakaeaaefrykygydmpcdvlakrmanlsq
iytqraymrplgviltfvsvdeelgpsiyktdpagyyvgykatatgpkqqeittnlenhf
kkskidhineeswekvvefaithmidalgtefskndlevgvatkdkfftlsaenieerlv
aiaeq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7ls6B (B:)
mtdrysfslttfspsgklgqidyaltavkqgvtslgikatngvviatekksssplamset
lskvslltpdigavysgmgpdyrvlvdksrkvahtsykriygeypptkllvsevakimqe
atqsggvrpfgvslliaghdefngfslyqvdpsgsyfpwkataigkgsvaaktflekrwn
deleledaihialltlkesvegefngdtielaiigdenpdllgytgiptdkgprfrklts
qeindrleal

    Sequence, based on observed residues (ATOM records): (download) 
    >7ls6B (B:)
drysfslttfspsgklgqidyaltavkqgvtslgikatngvviatekksssplamsetls
kvslltpdigavysgmgpdyrvlvdksrkvahtsykriygeypptkllvsevakimqeat
qsggvrpfgvslliaghdefngfslyqvdpsgsyfpwkataigkgsvaaktflekrwnde
leledaihialltlkesvegefngdtielaiigdenpdllgytgiptdkgprfrkltsqe
indrlea

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >7ls6C (C:)
mgsrrydsrttifspegrlyqveyalesishagtaigimasdgivlaaerkvtstlleqd
tsteklyklndkiavavagltadaeilintarihaqnylktynedipveilvrrlsdikq
gytqhgglrpfgvsfiyagyddrygyqlytsnpsgnytgwkaisvgantsaaqtllqmdy
kddmkvddaielalktlskttdssaltydrlefatirkgandgevyqkifkpqeikdilv
ktgitkkdedeeadedmk

    Sequence, based on observed residues (ATOM records): (download) 
    >7ls6C (C:)
ydsrttifspegrlyqveyalesishagtaigimasdgivlaaerkvtstlleqdtstek
lyklndkiavavagltadaeilintarihaqnylktynedipveilvrrlsdikqgytqh
gglrpfgvsfiyagyddrygyqlytsnpsgnytgwkaisvgantsaaqtllqmdykddmk
vddaielalktlskttdssaltydrlefatirkevyqkifkpqeikdilvktgi

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >7ls6D (D:)
msgydralsifspdghifqveyaleavkrgtcavgvkgkncvvlgcerrstlklqdtrit
pskvskidshvvlsfsglnadsriliekarveaqshrltledpvtveyltryvagvqqry
tqsggvrpfgvstliagfdprddepklyqtepsgiysswsaqtigrnsktvrefleknyd
rkeppatveecvkltvrsllevvqtgaknieitvvkpdsdivalsseeinqyvtqieqek
qeqqeqdkkkksnh

    Sequence, based on observed residues (ATOM records): (download) 
    >7ls6D (D:)
ydralsifspdghifqveyaleavkrgtcavgvkgkncvvlgcerrstlklqdtritpsk
vskidshvvlsfsglnadsriliekarveaqshrltledpvtveyltryvagvqqrytqs
ggvrpfgvstliagfdprddepklyqtepsgiysswsaqtigrnsktvrefleknydrke
ppatveecvkltvrsllevvqtgaknieitvvkpdsdivalsseeinqyvtqieq

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >7ls6E (E:)
mfltrseydrgvstfspegrlfqveysleaiklgstaigiatkegvvlgvekratsplle
sdsiekiveidrhigcamsgltadarsmiehartaavthnlyydedinvesltqsvcdla
lrfgegasgeerlmsrpfgvalliaghdaddgyqlfhaepsgtfyrynakaigsgsegaq
aellnewhssltlkeaellvlkilkqvmeekldennaqlscitkqdgfkiydnektaeli
kelkekeaaespeeadvems

    Sequence, based on observed residues (ATOM records): (download) 
    >7ls6E (E:)
mfltrseydrgvstfspegrlfqveysleaiklgstaigiatkegvvlgvekratsplle
sdsiekiveidrhigcamsgltadarsmiehartaavthnlyydedinvesltqsvcdla
lrfgegasgeerlmsrpfgvalliaghdaddgyqlfhaepsgtfyrynakaigsgsegaq
aellnewhssltlkeaellvlkilkqvmeekldennaqlscitkqdgfkiydnektaeli
kelkekeaa

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >7ls6F (F:)
mfrnnydgdtvtfsptgrlfqveyaleaikqgsvtvglrsnthavlvalkrnadelssyq
kkiikcdehmglslaglapdarvlsnylrqqcnysslvfnrklaveraghllcdkaqknt
qsyggrpygvglliigydksgahllefqpsgnvtelygtaigarsqgaktylertldtfi
kidgnpdelikagveaisqslrdesltvdnlsiaivgkdtpftiydgeavakyi

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >7ls6G (G:)
mtsigtgydlsnsvfspdgrnfqveyavkavengttsigikcndgvvfaveklitskllv
pqknvkiqvvdrhigcvysglipdgrhlvnrgreeaasfkklyktpipipafadrlgqyv
qahtlynsvrpfgvstifggvdkngahlymlepsgsywgykgaatgkgrqsakaeleklv
dhhpeglsareavkqaakiiylahednkekdfeleiswcslsetnglhkfvkgdllqeai
dfaqkeingdddededdsdnvmssddenapvatnanattdqegdihle

    Sequence, based on observed residues (ATOM records): (download) 
    >7ls6G (G:)
tsigtgydlsnsvfspdgrnfqveyavkavengttsigikcndgvvfaveklitskllvp
qknvkiqvvdrhigcvysglipdgrhlvnrgreeaasfkklyktpipipafadrlgqyvq
ahtlynsvrpfgvstifggvdkngahlymlepsgsywgykgaatgkgrqsakaeleklvd
hhpeglsareavkqaakiiylahednkekdfeleiswcslsetnglhkfvkgdllqeaid
faqke

  • Chain 'H':
    No sequence available.

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >7ls6I (I:)
maglsfdnyqrnnflaenshtqpkatstgttivgvkfnngvviaadtrstqgpivadknc
aklhrispkiwcagagtaadteavtqligsnielhslytsreprvvsalqmlkqhlfkyq
ghigaylivagvdptgshlfsihahgstdvgyylslgsgslaamavleshwkqdltkeea
iklasdaiqagiwndlgsgsnvdvcvmeigkdaeylrnyltpnvreekqksykfprgtta
vlkesivnicdiqeeqvdita

    Sequence, based on observed residues (ATOM records): (download) 
    >7ls6I (I:)
aglsfdnyqrnnflaenshtqpkatstgttivgvkfnngvviaadaklhrispkiwcaga
gtaadteavtqligsnielhslytsreprvvsalqmlkqhlfkyqghigaylivagvdpt
gshlfsihahgstdvgyylslgsgslaamavleshwkqdltkeeaiklasdaiqagnvdv
cvmeigkdaeylrnylvlkesivni

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >7ls6J (J:)
msdpssinggivvamtgkdcvaiacdlrlgsqslgvsnkfekifhyghvflgitglatdv
ttlnemfryktnlyklkeeraiepetftqlvssslyerrfgpyfvgpvvaginsksgkpf
iagfdligcideakdfivsgtasdqlfgmceslyepnlepedlfetisqallnaadrdal
sgwgavvyiikkdevvkrylkmrqd

    Sequence, based on observed residues (ATOM records): (download) 
    >7ls6J (J:)
nggivvamtgkdcvaiacdlfekifhyghvflgitglatdvttlnemfryktnlyklkee
raiepetftqlvssslyerrfgpyfvgpvvaginsksgkpfiagfdligcideakdfivs
gtasdqlfgmceslyepnlepedlfetisqallnawgavvyiikkdevvkryl

  • Chain 'K':
    Sequence, based on SEQRES records: (download) 
    >7ls6K (K:)
mdiilgirvqdsvilasskavtrgisvlkdsddktrqlsphtlmsfageagdtvqfaeyi
qaniqlysiredyelspqavssfvrqelaksirsrrpyqvnvliggydkkknkpelyqid
ylgtkvelpygahgysgfytfslldhhyrpdmtteegldllklcvqelekrmpmdfkgvi
vkivdkdgirqvddfqaq

    Sequence, based on observed residues (ATOM records): (download) 
    >7ls6K (K:)
mdiilgirvqdsvilasskavtrgisvddktrqlsphtlmsfageagdtvqfaeyiqani
qlysiredyelspqavssfvrqelaksirsrrpyqvnvliggydkkknkpelyqidylgt
kvelpygahgysgfytfslldhhyrpdmtteegldllklcvqelekrmpmdfkgvivkiv
dkdgirqvddf

  • Chain 'L':
    No sequence available.

  • Chain 'M':
    No sequence available.

  • Chain 'O':
    No sequence available.

  • Chain 'P':
    No sequence available.