PDB entry 7bsj

View 7bsj on RCSB PDB site
Description: Crystal structure of human ME2 R484W
Class: hydrolase
Keywords: malate dehydrogenase, NAD-dependent malic enzyme, HYDROLASE
Deposited on 2020-03-30, released 2021-02-10
The last revision prior to the SCOPe 2.07 freeze date was dated 2021-02-24, with a file datestamp of 2021-02-19.
Experiment type: XRAY
Resolution: 2.48 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: NAD-dependent malic enzyme, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: ME2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P23368 (1-End)
      • engineered mutation (465)
    Domains in SCOPe 2.07: d7bsja1, d7bsja2
  • Chain 'B':
    Compound: NAD-dependent malic enzyme, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: ME2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P23368
      • engineered mutation (465)
    Domains in SCOPe 2.07: d7bsjb1, d7bsjb2
  • Heterogens: FUM, TTN, NAD, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7bsjA (A:)
mhikekgkplmlnprtnkgmaftlqerqmlglqgllppkietqdiqalrfhrnlkkmtsp
lekyiyimgiqerneklfyrilqddieslmpivytptvglacsqyghifrrpkglfisis
drghvrsivdnwpenhvkavvvtdgerilglgdlgvygmgipvgklclytacagirpdrc
lpvcidvgtdniallkdpfymglyqkrdrtqqyddlidefmkaitdrygrntliqfedfg
nhnafrflrkyrekyctfnddiqgtaavalagllaaqkviskpisehkilflgageaalg
ianlivmsmvenglseqeaqkkiwmfdkygllvkgrkakidsyqepfthsapesipdtfe
davnilkpstiigvagagrlftpdviramasinerpvifalsnptaqaectaeeaytlte
grclfasgspfgpvkltdgrvftpgqgnnvyifpgvalavilcntwhisdsvfleaakal
tsqltdeelaqgrlypplaniqevsiniaikvteylyankmafrypepedkakyvkertw
rseydsllpdvyewpesassppvite

    Sequence, based on observed residues (ATOM records): (download) 
    >7bsjA (A:)
hikekgkplmlnprtnkgmaftlqerqmlglqgllppkietqdiqalrfhrnlkkmtspl
ekyiyimgiqerneklfyrilqddieslmpivytptvglacsqyghifrrpkglfisisd
rghvrsivdnwpenhvkavvvtdgerilglgdlgvygmgipvgklclytacagirpdrcl
pvcidvgtdniallkdpfymglyqkrdrtqqyddlidefmkaitdrygrntliqfedfgn
hnafrflrkyrekyctfnddiqgtaavalagllaaqkviskpisehkilflgageaalgi
anlivmsmvenglseqeaqkkiwmfdkygllvkgrkakidsyqepfthsapesipdtfed
avnilkpstiigvagagrlftpdviramasinerpvifalsnptaqaectaeeaytlteg
rclfasgspfgpvkltdgrvftpgqgnnvyifpgvalavilcntwhisdsvfleaakalt
sqltdeelaqgrlypplaniqevsiniaikvteylyankmafrypepedkakyvkertwr
seydsllpdvyew

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7bsjB (B:)
mhikekgkplmlnprtnkgmaftlqerqmlglqgllppkietqdiqalrfhrnlkkmtsp
lekyiyimgiqerneklfyrilqddieslmpivytptvglacsqyghifrrpkglfisis
drghvrsivdnwpenhvkavvvtdgerilglgdlgvygmgipvgklclytacagirpdrc
lpvcidvgtdniallkdpfymglyqkrdrtqqyddlidefmkaitdrygrntliqfedfg
nhnafrflrkyrekyctfnddiqgtaavalagllaaqkviskpisehkilflgageaalg
ianlivmsmvenglseqeaqkkiwmfdkygllvkgrkakidsyqepfthsapesipdtfe
davnilkpstiigvagagrlftpdviramasinerpvifalsnptaqaectaeeaytlte
grclfasgspfgpvkltdgrvftpgqgnnvyifpgvalavilcntwhisdsvfleaakal
tsqltdeelaqgrlypplaniqevsiniaikvteylyankmafrypepedkakyvkertw
rseydsllpdvyewpesassppvite

    Sequence, based on observed residues (ATOM records): (download) 
    >7bsjB (B:)
ikekgkplmlnprtnkgmaftlqerqmlglqgllppkietqdiqalrfhrnlkkmtsple
kyiyimgiqerneklfyrilqddieslmpivytptvglacsqyghifrrpkglfisisdr
ghvrsivdnwpenhvkavvvtdgerilglgdlgvygmgipvgklclytacagirpdrclp
vcidvgtdniallkdpfymglyqkrdrtqqyddlidefmkaitdrygrntliqfedfgnh
nafrflrkyrekyctfnddiqgtaavalagllaaqkviskpisehkilflgageaalgia
nlivmsmvenglseqeaqkkiwmfdkygllvkgrkakidsyqepfthsapesipdtfeda
vnilkpstiigvagagrlftpdviramasinerpvifalsnptaqaectaeeaytltegr
clfasgspfgpvkltdgrvftpgqgnnvyifpgvalavilcntwhisdsvfleaakalts
qltdeelaqgrlypplaniqevsiniaikvteylyankmafrypepedkakyvkertwrs
eydsllpdvyew