PDB entry 6ztc

View 6ztc on RCSB PDB site
Description: crystal structure of prostaglandin d2 synthase in complex with fragment 1a at 1.84a resolution.
Class: isomerase
Keywords: prostaglandin biosynthesis, fatty acid biosynthesis, prostaglandin d2 synthase, pgds, asthma, cytoplasm, isomerase, lipid synthesis
Deposited on 2020-07-17, released 2021-07-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-07-28, with a file datestamp of 2021-07-23.
Experiment type: XRAY
Resolution: 1.84 Å
R-factor: N/A
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: hematopoietic prostaglandin d synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: HPGDS, GSTS, PGDS, PTGDS2
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60760 (1-199)
      • expression tag (0)
    Domains in SCOPe 2.08: d6ztca1, d6ztca2
  • Chain 'B':
    Compound: hematopoietic prostaglandin d synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: HPGDS, GSTS, PGDS, PTGDS2
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60760 (1-199)
      • expression tag (0)
    Domains in SCOPe 2.08: d6ztcb1, d6ztcb2, d6ztcb3
  • Heterogens: QPN, GSH, MG, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >6ztcA (A:)
    gmpnykltyfnmrgraeiiryifayldiqyedhrieqadwpeikstlpfgkipilevdgl
    tlhqslaiaryltkntdlagntemeqchvdaivdtlddfmscfpwaekkqdvkeqmfnel
    ltynaphlmqdldtylggrewlignsvtwadfyweicsttllvfkpdlldnhprlvtlrk
    kvqaipavanwikrrpqtkl
    

    Sequence, based on observed residues (ATOM records): (download)
    >6ztcA (A:)
    mpnykltyfnmrgraeiiryifayldiqyedhrieqadwpeikstlpfgkipilevdglt
    lhqslaiaryltkntdlagntemeqchvdaivdtlddfmscfpwaekkqdvkeqmfnell
    tynaphlmqdldtylggrewlignsvtwadfyweicsttllvfkpdlldnhprlvtlrkk
    vqaipavanwikrrpqtkl
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >6ztcB (B:)
    gmpnykltyfnmrgraeiiryifayldiqyedhrieqadwpeikstlpfgkipilevdgl
    tlhqslaiaryltkntdlagntemeqchvdaivdtlddfmscfpwaekkqdvkeqmfnel
    ltynaphlmqdldtylggrewlignsvtwadfyweicsttllvfkpdlldnhprlvtlrk
    kvqaipavanwikrrpqtkl