PDB entry 6z89

View 6z89 on RCSB PDB site
Description: human GTP cyclohydrolase I in complex with allosteric inhibitor
Class: hydrolase
Keywords: GTP cyclohydrolase I, EC:3.5.4.16, Tetrahydrobiopterin (BH4) synthesis, Cytosol, Zinc Ion Binding, Hydrolase Activity, Metal Ion Binding, Nucleotide Binding, allosteric inhibitor, HYDROLASE
Deposited on 2020-06-02, released 2020-12-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-12-23, with a file datestamp of 2020-12-18.
Experiment type: XRAY
Resolution: 2.37 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: GTP cyclohydrolase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: GCH1, DYT5, GCH
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6z89a_
  • Chain 'B':
    Compound: GTP cyclohydrolase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: GCH1, DYT5, GCH
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6z89b_
  • Chain 'C':
    Compound: GTP cyclohydrolase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: GCH1, DYT5, GCH
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: GTP cyclohydrolase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: GCH1, DYT5, GCH
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6z89d_
  • Chain 'E':
    Compound: GTP cyclohydrolase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: GCH1, DYT5, GCH
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6z89e_
  • Heterogens: QBK, ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6z89A (A:)
mhhhhhhgsddddkrpeaksaqpadgwkgerprseednelnlpnlaaayssilsslgenp
qrqgllktpwraasamqfftkgyqetisdvlndaifdedhdemvivkdidmfsmcehhlv
pfvgkvhigylpnkqvlglsklariveiysrrlqvqerltkqiavaitealrpagvgvvv
eathmcmvmrgvqkmnsktvtstmlgvfredpktreefltlirs

    Sequence, based on observed residues (ATOM records): (download) 
    >6z89A (A:)
prseednelnlpnlaaayssilsslgenpqrqgllktpwraasamqfftkgyqetisdvl
ndaifdedhdemvivkdidmfsmcehhlvpfvgkvhigylpnkqvlglsklariveiysr
rlqvqerltkqiavaitealrpagvgvvveathmnsktvtstmlgvfredpktreefltl
i

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6z89B (B:)
mhhhhhhgsddddkrpeaksaqpadgwkgerprseednelnlpnlaaayssilsslgenp
qrqgllktpwraasamqfftkgyqetisdvlndaifdedhdemvivkdidmfsmcehhlv
pfvgkvhigylpnkqvlglsklariveiysrrlqvqerltkqiavaitealrpagvgvvv
eathmcmvmrgvqkmnsktvtstmlgvfredpktreefltlirs

    Sequence, based on observed residues (ATOM records): (download) 
    >6z89B (B:)
seednelnlpnlaaayssilsslgenpqrqgllktpwraasamqfftkgyqetidhdemv
ivkdidmfsmcehhlvpfvgkvhigylpnkqvlglsklariveiysrrlqvqerltkqia
vaitealrpagvgvvveathmcmvmnsktvtstmlgvfredpktreefltlir

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6z89D (D:)
mhhhhhhgsddddkrpeaksaqpadgwkgerprseednelnlpnlaaayssilsslgenp
qrqgllktpwraasamqfftkgyqetisdvlndaifdedhdemvivkdidmfsmcehhlv
pfvgkvhigylpnkqvlglsklariveiysrrlqvqerltkqiavaitealrpagvgvvv
eathmcmvmrgvqkmnsktvtstmlgvfredpktreefltlirs

    Sequence, based on observed residues (ATOM records): (download) 
    >6z89D (D:)
prseednelnlpnlaaayssilsslgenpqrqgllktpwraasamqfftkgyqetisdvl
ndaifdedhdemvivkdidmfsmcehhlvpfvgkvhigylpnkqvlglsklariveiysr
rlqvqerltkqiavaitealrpagvgvvveathsktvtstmlgvfredpktreefltlir

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6z89E (E:)
mhhhhhhgsddddkrpeaksaqpadgwkgerprseednelnlpnlaaayssilsslgenp
qrqgllktpwraasamqfftkgyqetisdvlndaifdedhdemvivkdidmfsmcehhlv
pfvgkvhigylpnkqvlglsklariveiysrrlqvqerltkqiavaitealrpagvgvvv
eathmcmvmrgvqkmnsktvtstmlgvfredpktreefltlirs

    Sequence, based on observed residues (ATOM records): (download) 
    >6z89E (E:)
prseednelnlpnlaaayssilsslgenpqrqgllktpwraasamqfftkgyqetihdem
vivkdidmfsmcehhlvpfvgkvhigyvlglsklariveiysrrlqvqerltkqiavait
ealrpagvgvvveathmcmnsktvtstmlgvfredpktreefltlir