PDB entry 6z6v

View 6z6v on RCSB PDB site
Description: Globular head of C1q in complex with the nanobody C1qNb75
Class: immune system
Keywords: complement, antibody, nanobody, C1q, IMMUNE SYSTEM
Deposited on 2020-05-29, released 2020-06-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-09-16, with a file datestamp of 2020-09-11.
Experiment type: XRAY
Resolution: 2.19 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: complement c1q subcomponent subunit a
    Species: Homo sapiens [TaxId:9606]
    Gene: c1qa
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6z6va_
  • Chain 'B':
    Compound: complement c1q subcomponent subunit b
    Species: Homo sapiens [TaxId:9606]
    Gene: C1QB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6z6vb_
  • Chain 'C':
    Compound: complement c1q subcomponent subunit c
    Species: Homo sapiens [TaxId:9606]
    Gene: C1QC, C1QG
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6z6vc_
  • Chain 'D':
    Compound: complement c1q subcomponent subunit a
    Species: Homo sapiens [TaxId:9606]
    Gene: c1qa
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6z6vd_
  • Chain 'E':
    Compound: complement c1q subcomponent subunit b
    Species: Homo sapiens [TaxId:9606]
    Gene: C1QB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6z6ve_
  • Chain 'F':
    Compound: complement c1q subcomponent subunit c
    Species: Homo sapiens [TaxId:9606]
    Gene: C1QC, C1QG
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6z6vf_
  • Chain 'G':
    Compound: Nanobody C1q75
    Species: LAMA GLAMA [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 6Z6V
    Domains in SCOPe 2.08: d6z6vg1, d6z6vg2
  • Chain 'H':
    Compound: Nanobody C1q75
    Species: LAMA GLAMA [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 6Z6V
    Domains in SCOPe 2.08: d6z6vh1, d6z6vh2
  • Heterogens: NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6z6vA (A:)
kdqprpafsairrnppmggnvvifdtvitnqeepyqnhsgrfvctvpgyyyftfqvlsqw
eiclsivsssrgqvrrslgfcdttnkglfqvvsggmvlqlqqgdqvwvekdpkkghiyqg
seadsvfsgflifpsa

    Sequence, based on observed residues (ATOM records): (download) 
    >6z6vA (A:)
prpafsairrnppmggnvvifdtvitnqeepyqnhsgrfvctvpgyyyftfqvlsqweic
lsivsssrgqvrrslgfcdttnkglfqvvsggmvlqlqqgdqvwvekdpkkghiyqgsea
dsvfsgflifpsa

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6z6vB (B:)
tqkiafsatrtinvplrrdqtirfdhvitnmnnnyeprsgkftckvpglyyftyhassrg
nlcvnlmrgreraqkvvtfcdyayntfqvttggmvlkleqgenvflqatdknsllgmega
nsifsgfllfpdmeahhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6z6vB (B:)
tqkiafsatrtinvplrrdqtirfdhvitnmnnnyeprsgkftckvpglyyftyhassrg
nlcvnlmrgreraqkvvtfcdyayntfqvttggmvlkleqgenvflqatdknsllgmega
nsifsgfllfpdm

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6z6vC (C:)
gsgkqkfqsvftvtrqthqppapnslirfnavltnpqgdydtstgkftckvpglyyfvyh
ashtanlcvllyrsgvkvvtfcghtsktnqvnsggvllrlqvgeevwlavndyydmvgiq
gsdsvfsgfllfpdgsaka

    Sequence, based on observed residues (ATOM records): (download) 
    >6z6vC (C:)
qkfqsvftvtrqthqppapnslirfnavltnpqgdydtstgkftckvpglyyfvyhasht
anlcvllyrsgvkvvtfcghtsktnqvnsggvllrlqvgeevwlavndyydmvgiqgsds
vfsgfllf

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6z6vD (D:)
kdqprpafsairrnppmggnvvifdtvitnqeepyqnhsgrfvctvpgyyyftfqvlsqw
eiclsivsssrgqvrrslgfcdttnkglfqvvsggmvlqlqqgdqvwvekdpkkghiyqg
seadsvfsgflifpsa

    Sequence, based on observed residues (ATOM records): (download) 
    >6z6vD (D:)
qprpafsairrnppmggnvvifdtvitnqeepyqnhsgrfvctvpgyyyftfqvlsqwei
clsivsssrgqvrrslgfcdttnkglfqvvsggmvlqlqqgdqvwvekdpkkghiyqgse
adsvfsgflifps

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6z6vE (E:)
tqkiafsatrtinvplrrdqtirfdhvitnmnnnyeprsgkftckvpglyyftyhassrg
nlcvnlmrgreraqkvvtfcdyayntfqvttggmvlkleqgenvflqatdknsllgmega
nsifsgfllfpdmeahhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6z6vE (E:)
tqkiafsatrtinvplrrdqtirfdhvitnmnnnyeprsgkftckvpglyyftyhassrg
nlcvnlmrgreraqkvvtfcdyayntfqvttggmvlkleqgenvflqatdknsllgmega
nsifsgfllfpdm

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6z6vF (F:)
gsgkqkfqsvftvtrqthqppapnslirfnavltnpqgdydtstgkftckvpglyyfvyh
ashtanlcvllyrsgvkvvtfcghtsktnqvnsggvllrlqvgeevwlavndyydmvgiq
gsdsvfsgfllfpdgsaka

    Sequence, based on observed residues (ATOM records): (download) 
    >6z6vF (F:)
kqkfqsvftvtrqthqppapnslirfnavltnpqgdydtstgkftckvpglyyfvyhash
tanlcvllyrsgvkvvtfcghtsktnqvnsggvllrlqvgeevwlavndyydmvgiqgsd
svfsgfllfpd

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >6z6vG (G:)
qvqlvetggglvqaggslrlscaasgrtfnndvmawfrqapgterefvalitagggthya
dsvkgrfvisrdndknmaylqmnslksedtaiyycgadenppgwpsrwssaydywgqgtq
vtvsshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6z6vG (G:)
qlvetggglvqaggslrlscaasgrtfnndvmawfrqapgterefvalitagggthyads
vkgrfvisrdndknmaylqmnslksedtaiyycgadenppgwpsrwssaydywgqgtqvt
vs

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6z6vH (H:)
qvqlvetggglvqaggslrlscaasgrtfnndvmawfrqapgterefvalitagggthya
dsvkgrfvisrdndknmaylqmnslksedtaiyycgadenppgwpsrwssaydywgqgtq
vtvsshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6z6vH (H:)
vqlvetggglvqaggslrlscaasgrtfnndvmawfrqapgterefvalitagggthyad
svkgrfvisrdndknmaylqmnslksedtaiyycgadenppgwpsrwssaydywgqgtqv
tvs