PDB entry 6yt6

View 6yt6 on RCSB PDB site
Description: FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH N-Methyl-N-(3-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-pyrimidin-4-ylamino]-methyl}-pyridin-2-yl)-methanesulfonamide
Class: transferase
Keywords: protein tyrosine kinase, ATP binding, transferase, transferase-inhibitor complex
Deposited on 2020-04-23, released 2021-02-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-06-02, with a file datestamp of 2021-05-28.
Experiment type: XRAY
Resolution: 1.54 Å
R-factor: N/A
AEROSPACI score: 0.55 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Focal adhesion kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PTK2, FAK, FAK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6yt6a_
  • Chain 'B':
    Compound: Focal adhesion kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PTK2, FAK, FAK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6yt6b_
  • Heterogens: PKE, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6yt6A (A:)
gsgstrdyeiqrerielgrcigegqfgdvhqgiymspenpalavaiktcknctsdsvrek
flqealtmrqfdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilya
yqlstalayleskrfvhrdiaarnvlvssndcvklgdfglsrymedstyykaskgklpik
wmapesinfrrftsasdvwmfgvcmweilmhgvkpfqgvknndvigriengerlpmppnc
pptlyslmtkcwaydpsrrprftelkaqlstileeekaqqee

    Sequence, based on observed residues (ATOM records): (download) 
    >6yt6A (A:)
dyeiqrerielgrcigegqfgdvhqgiymsnpalavaiktcknctsdsvrekflqealtm
rqfdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilyayqlstala
yleskrfvhrdiaarnvlvssndcvklgdfglslpikwmapesinfrrftsasdvwmfgv
cmweilmhgvkpfqgvknndvigriengerlpmppncpptlyslmtkcwaydpsrrprft
elkaqlstileeekaq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6yt6B (B:)
gsgstrdyeiqrerielgrcigegqfgdvhqgiymspenpalavaiktcknctsdsvrek
flqealtmrqfdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilya
yqlstalayleskrfvhrdiaarnvlvssndcvklgdfglsrymedstyykaskgklpik
wmapesinfrrftsasdvwmfgvcmweilmhgvkpfqgvknndvigriengerlpmppnc
pptlyslmtkcwaydpsrrprftelkaqlstileeekaqqee

    Sequence, based on observed residues (ATOM records): (download) 
    >6yt6B (B:)
dyeiqrerielgrcigegqfgdvhqgiymspenpalavaiktcknctsdsvrekflqeal
tmrqfdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilyayqlsta
layleskrfvhrdiaarnvlvssndcvklgdfglklpikwmapesinfrrftsasdvwmf
gvcmweilmhgvkpfqgvknndvigriengerlpmppncpptlyslmtkcwaydpsrrpr
ftelkaqlstileeekaq