PDB entry 6yt2

View 6yt2 on RCSB PDB site
Description: Crystal Structure of human monoamine oxidase B in complex with Diphenylene iodonium (DPI)
Class: flavoprotein
Keywords: monoamine oxidase, drug target, neurodegeneration, ROS, flavin, mitochondrial membrane, FLAVOPROTEIN
Deposited on 2020-04-23, released 2020-06-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-08-19, with a file datestamp of 2020-08-14.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: N/A
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: amine oxidase [flavin-containing] b
    Species: Homo sapiens [TaxId:9606]
    Gene: MAOB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6yt2a1, d6yt2a2
  • Chain 'B':
    Compound: amine oxidase [flavin-containing] b
    Species: Homo sapiens [TaxId:9606]
    Gene: MAOB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6yt2b1, d6yt2b2
  • Heterogens: PJW, FAD, C15, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6yt2A (A:)
snkcdvvvvgggisgmaaakllhdsglnvvvleardrvggrtytlrnqkvkyvdlggsyv
gptqnrilrlakelgletykvneverlihhvkgksypfrgpfppvwnpityldhnnfwrt
mddmgreipsdapwkaplaeewdnmtmkelldklcwtesakqlatlfvnlcvtaethevs
alwflwyvkqcggttriisttnggqerkfvggsgqvserimdllgdrvklerpviyidqt
renvlvetlnhemyeakyvisaipptlgmkihfnpplpmmrnqmitrvplgsvikcivyy
kepfwrkkdycgtmiidgeeapvaytlddtkpegnyaaimgfilahkarklarltkeerl
kklcelyakvlgslealepvhyeeknwceeqysggcyttyfppgiltqygrvlrqpvdri
yfagtetathwsgymegaveageraareilhamgkipedeiwqsepesvdvpaqpitttf
lerhlpsvpgllrliglttifsatalgflahkrgllvrv

    Sequence, based on observed residues (ATOM records): (download) 
    >6yt2A (A:)
snkcdvvvvgggisgmaaakllhdsglnvvvleardrvggrtytlrnqkvkyvdlggsyv
gptqnrilrlakelgletykvneverlihhvkgksypfrgpfppvwnpityldhnnfwrt
mddmgreipsdapwkaplaeewdnmtmkelldklcwtesakqlatlfvnlcvtaethevs
alwflwyvkqcggttriisttnggqerkfvggsgqvserimdllgdrvklerpviyidqt
renvlvetlnhemyeakyvisaipptlgmkihfnpplpmmrnqmitrvplgsvikcivyy
kepfwrkkdycgtmiidgeeapvaytlddtkpegnyaaimgfilahkarklarltkeerl
kklcelyakvlgslealepvhyeeknwceeqysggcyttyfppgiltqygrvlrqpvdri
yfagtetathwsgymegaveageraareilhamgkipedeiwqsepesvdvpaqpitttf
lerhlpsvpgllrligltti

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6yt2B (B:)
snkcdvvvvgggisgmaaakllhdsglnvvvleardrvggrtytlrnqkvkyvdlggsyv
gptqnrilrlakelgletykvneverlihhvkgksypfrgpfppvwnpityldhnnfwrt
mddmgreipsdapwkaplaeewdnmtmkelldklcwtesakqlatlfvnlcvtaethevs
alwflwyvkqcggttriisttnggqerkfvggsgqvserimdllgdrvklerpviyidqt
renvlvetlnhemyeakyvisaipptlgmkihfnpplpmmrnqmitrvplgsvikcivyy
kepfwrkkdycgtmiidgeeapvaytlddtkpegnyaaimgfilahkarklarltkeerl
kklcelyakvlgslealepvhyeeknwceeqysggcyttyfppgiltqygrvlrqpvdri
yfagtetathwsgymegaveageraareilhamgkipedeiwqsepesvdvpaqpitttf
lerhlpsvpgllrliglttifsatalgflahkrgllvrv

    Sequence, based on observed residues (ATOM records): (download) 
    >6yt2B (B:)
snkcdvvvvgggisgmaaakllhdsglnvvvleardrvggrtytlrnqkvkyvdlggsyv
gptqnrilrlakelgletykvneverlihhvkgksypfrgpfppvwnpityldhnnfwrt
mddmgreipsdapwkaplaeewdnmtmkelldklcwtesakqlatlfvnlcvtaethevs
alwflwyvkqcggttriisttnggqerkfvggsgqvserimdllgdrvklerpviyidqt
renvlvetlnhemyeakyvisaipptlgmkihfnpplpmmrnqmitrvplgsvikcivyy
kepfwrkkdycgtmiidgeeapvaytlddtkpegnyaaimgfilahkarklarltkeerl
kklcelyakvlgslealepvhyeeknwceeqysggcyttyfppgiltqygrvlrqpvdri
yfagtetathwsgymegaveageraareilhamgkipedeiwqsepesvdvpaqpitttf
lerhlpsvpgllrli