PDB entry 6yq1

View 6yq1 on RCSB PDB site
Description: FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH N-Methyl-N-(3-{[2-(2-oxo-1,2,3,4-tetrahydro-quinolin-6-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-pyridin-2-yl)-methanesulfonamide
Class: transferase
Keywords: protein tyrosine kinase, ATP binding, transferase, transferase-inhibitor complex
Deposited on 2020-04-16, released 2021-02-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-06-02, with a file datestamp of 2021-05-28.
Experiment type: XRAY
Resolution: 1.78 Å
R-factor: N/A
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Focal adhesion kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PTK2, FAK, FAK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6yq1a_
  • Chain 'B':
    Compound: Focal adhesion kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PTK2, FAK, FAK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q05397 (3-End)
      • expression tag (2)
    Domains in SCOPe 2.08: d6yq1b1, d6yq1b2
  • Chain 'C':
    Compound: Focal adhesion kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PTK2, FAK, FAK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6yq1c_
  • Chain 'D':
    Compound: Focal adhesion kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PTK2, FAK, FAK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6yq1d_
  • Heterogens: P7N, NA, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6yq1A (A:)
gsgstrdyeiqrerielgrcigegqfgdvhqgiymspenpalavaiktcknctsdsvrek
flqealtmrqfdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilya
yqlstalayleskrfvhrdiaarnvlvssndcvklgdfglsrymedstyykaskgklpik
wmapesinfrrftsasdvwmfgvcmweilmhgvkpfqgvknndvigriengerlpmppnc
pptlyslmtkcwaydpsrrprftelkaqlstileeekaqqee

    Sequence, based on observed residues (ATOM records): (download) 
    >6yq1A (A:)
yeiqrerielgrcigegqfgdvhqgiymspenpalavaiktcknctsdsvrekflqealt
mrqfdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilyayqlstal
ayleskrfvhrdiaarnvlvssndcvklgdfglsrymedstyykaklpikwmapesinfr
rftsasdvwmfgvcmweilmhgvkpfqgvknndvigriengerlpmppncpptlyslmtk
cwaydpsrrprftelkaqlstileeekaq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6yq1B (B:)
gsgstrdyeiqrerielgrcigegqfgdvhqgiymspenpalavaiktcknctsdsvrek
flqealtmrqfdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilya
yqlstalayleskrfvhrdiaarnvlvssndcvklgdfglsrymedstyykaskgklpik
wmapesinfrrftsasdvwmfgvcmweilmhgvkpfqgvknndvigriengerlpmppnc
pptlyslmtkcwaydpsrrprftelkaqlstileeekaqqee

    Sequence, based on observed residues (ATOM records): (download) 
    >6yq1B (B:)
gstrdyeiqrerielgrcigegqfgdvhqgiymspenpalavaiktcknctsdsvrekfl
qealtmrqfdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilyayq
lstalayleskrfvhrdiaarnvlvssndcvklgdfglsrymedstyykgklpikwmape
sinfrrftsasdvwmfgvcmweilmhgvkpfqgvknndvigriengerlpmppncpptly
slmtkcwaydpsrrprftelkaqlstileeekaq

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6yq1C (C:)
gsgstrdyeiqrerielgrcigegqfgdvhqgiymspenpalavaiktcknctsdsvrek
flqealtmrqfdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilya
yqlstalayleskrfvhrdiaarnvlvssndcvklgdfglsrymedstyykaskgklpik
wmapesinfrrftsasdvwmfgvcmweilmhgvkpfqgvknndvigriengerlpmppnc
pptlyslmtkcwaydpsrrprftelkaqlstileeekaqqee

    Sequence, based on observed residues (ATOM records): (download) 
    >6yq1C (C:)
trdyeiqrerielgrcigegqfgdvhqgiymspenpalavaiktcknctsdsvrekflqe
altmrqfdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilyayqls
talayleskrfvhrdiaarnvlvssndcvklgdfglsrymklpikwmapesinfrrftsa
sdvwmfgvcmweilmhgvkpfqgvknndvigriengerlpmppncpptlyslmtkcwayd
psrrprftelkaqlstileeekaq

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6yq1D (D:)
gsgstrdyeiqrerielgrcigegqfgdvhqgiymspenpalavaiktcknctsdsvrek
flqealtmrqfdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilya
yqlstalayleskrfvhrdiaarnvlvssndcvklgdfglsrymedstyykaskgklpik
wmapesinfrrftsasdvwmfgvcmweilmhgvkpfqgvknndvigriengerlpmppnc
pptlyslmtkcwaydpsrrprftelkaqlstileeekaqqee

    Sequence, based on observed residues (ATOM records): (download) 
    >6yq1D (D:)
yeiqrerielgrcigegqfgdvhqgiymspenpalavaiktcknctsdsvrekflqealt
mrqfdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilyayqlstal
ayleskrfvhrdiaarnvlvssndcvklgdfglsrlpikwmapesinfrrftsasdvwmf
gvcmweilmhgvkpfqgvknndvigriengerlpmppncpptlyslmtkcwaydpsrrpr
ftelkaqlstileeekaq