PDB entry 6y08

View 6y08 on RCSB PDB site
Description: Mouse thymidylate synthase cocrystallized with dUMP and soaked in sulfamethoxazole
Class: transferase
Keywords: Fragment Screening, Fragment, Inhibitor, Thymidylate Synthase, TRANSFERASE
Deposited on 2020-02-06, released 2021-02-17
The last revision prior to the SCOPe 2.07 freeze date was dated 2021-02-17, with a file datestamp of 2021-02-12.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidylate synthase
    Species: Mus musculus [TaxId:10090]
    Gene: Tyms
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6y08a_
  • Chain 'B':
    Compound: Thymidylate synthase
    Species: Mus musculus [TaxId:10090]
    Gene: Tyms
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6y08b_
  • Heterogens: 08D, UMP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6y08A (A:)
mlvvgselqsdaqqlsaeaprhgelqylrqvehilrcgfkkedrtgtgtlsvfgmqarys
lrdefpllttkrvfwkgvleellwfikgstnakelsskgvriwdangsrdfldslgfsar
qegdlgpvygfqwrhfgaeykdmdsdysgqgvdqlqkvidtiktnpddrriimcawnpkd
lplmalppchalcqfyvvngelscqlyqrsgdmglgvpfniasyalltymiahitglqpg
dfvhtlgdahiylnhieplkiqlqreprpfpklkilrkvetiddfkvedfqiegynphpt
ikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >6y08A (A:)
hgelqylrqvehilrcgfkkedrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvlee
llwfikgstnakelsskgvriwdangsrdfldslgfsarqegdlgpvygfqwrhfgaeyk
dmdsdysgqgvdqlqkvidtiktnpddrriimcawnpkdlplmalppchalcqfyvvnge
lscqlyqrsgdmglgvpfniasyalltymiahitglqpgdfvhtlgdahiylnhieplki
qlqreprpfpklkilrkvetiddfkvedfqiegynphpt

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6y08B (B:)
mlvvgselqsdaqqlsaeaprhgelqylrqvehilrcgfkkedrtgtgtlsvfgmqarys
lrdefpllttkrvfwkgvleellwfikgstnakelsskgvriwdangsrdfldslgfsar
qegdlgpvygfqwrhfgaeykdmdsdysgqgvdqlqkvidtiktnpddrriimcawnpkd
lplmalppchalcqfyvvngelscqlyqrsgdmglgvpfniasyalltymiahitglqpg
dfvhtlgdahiylnhieplkiqlqreprpfpklkilrkvetiddfkvedfqiegynphpt
ikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >6y08B (B:)
gelqylrqvehilrcgfkkedrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvleel
lwfikgstnakelsskgvriwdangsrdfldslgfsarqegdlgpvygfqwrhfgaeykd
mdsdysgqgvdqlqkvidtiktnpddrriimcawnpkdlplmalppchalcqfyvvngel
scqlyqrsgdmglgvpfniasyalltymiahitglqpgdfvhtlgdahiylnhieplkiq
lqreprpfpklkilrkvetiddfkvedfqiegynphpt