PDB entry 6xm2

View 6xm2 on RCSB PDB site
Description: The structure of the 4A11.v7 antibody in complex with human TGFb2
Class: cytokine/immune system
Keywords: TGFb antibody, CYTOKINE, CYTOKINE-IMMUNE SYSTEM complex
Deposited on 2020-06-29, released 2021-07-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-07-07, with a file datestamp of 2021-07-02.
Experiment type: XRAY
Resolution: 1.91 Å
R-factor: N/A
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 4A11.v7 kappa light chain Fab (VL-CL) humanized
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6XM2 (0-218)
    Domains in SCOPe 2.08: d6xm2a_
  • Chain 'B':
    Compound: 4A11.v7 heavy chain Fab (VH-CH1) IgG1 humanized
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6XM2 (0-232)
    Domains in SCOPe 2.08: d6xm2b_
  • Chain 'C':
    Compound: 4A11.v7 kappa light chain Fab (VL-CL) humanized
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6XM2 (0-218)
    Domains in SCOPe 2.08: d6xm2c_
  • Chain 'D':
    Compound: 4A11.v7 heavy chain Fab (VH-CH1) IgG1 humanized
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6XM2 (0-232)
    Domains in SCOPe 2.08: d6xm2d_
  • Chain 'E':
    Compound: 4A11.v7 kappa light chain Fab (VL-CL) humanized
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6XM2 (0-218)
    Domains in SCOPe 2.08: d6xm2e_
  • Chain 'F':
    Compound: 4A11.v7 heavy chain Fab (VH-CH1) IgG1 humanized
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6XM2 (0-232)
    Domains in SCOPe 2.08: d6xm2f_
  • Chain 'G':
    Compound: 4A11.v7 kappa light chain Fab (VL-CL) humanized
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6XM2 (0-218)
    Domains in SCOPe 2.08: d6xm2g_
  • Chain 'H':
    Compound: 4A11.v7 heavy chain Fab (VH-CH1) IgG1 humanized
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6XM2 (0-232)
    Domains in SCOPe 2.08: d6xm2h_
  • Chain 'I':
    Compound: Transforming growth factor beta-2
    Species: Homo sapiens [TaxId:9606]
    Gene: TGFB2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6xm2i_
  • Chain 'J':
    Compound: Transforming growth factor beta-2
    Species: Homo sapiens [TaxId:9606]
    Gene: TGFB2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6xm2j_
  • Chain 'K':
    Compound: Transforming growth factor beta-2
    Species: Homo sapiens [TaxId:9606]
    Gene: TGFB2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6xm2k_
  • Chain 'L':
    Compound: Transforming growth factor beta-2
    Species: Homo sapiens [TaxId:9606]
    Gene: TGFB2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6xm2l_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6xm2A (A:)
eavltqspgtlslspgeratlscqssqsvynnnylswfqqkpgqpprlliygastltsgv
pdrfsgsgsgtdftltisrlepedfavyycaggysgssdkyafgggtkveikrtvaapsv
fifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysl
sstltlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >6xm2A (A:)
avltqspgtlslspgeratlscqssqsvynnnylswfqqkpgqpprlliygastltsgvp
drfsgsgsgtdftltisrlepedfavyycaggysgssdkyafgggtkveikrtvaapsvf
ifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysls
stltlskadyekhkvyacevthqglsspvtksfnrge

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6xm2B (B:)
eqqlqesgpglvkpsetlsltctvtgfslssytvnwvrqpagkglewigyisyggsayya
swangrftiskdssknqvslklssvtaadtavyfcarhmqvggaptgsmaafdpwgpgtl
vtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpa
vlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdktht

    Sequence, based on observed residues (ATOM records): (download) 
    >6xm2B (B:)
qqlqesgpglvkpsetlsltctvtgfslssytvnwvrqpagkglewigyisyggsayyas
wangrftiskdssknqvslklssvtaadtavyfcarhmqvggaptgsmaafdpwgpgtlv
tvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpav
lqssglyslssvvtvpsssltyicnvnhkpsntkvdkkvep

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6xm2C (C:)
eavltqspgtlslspgeratlscqssqsvynnnylswfqqkpgqpprlliygastltsgv
pdrfsgsgsgtdftltisrlepedfavyycaggysgssdkyafgggtkveikrtvaapsv
fifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysl
sstltlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >6xm2C (C:)
avltqspgtlslspgeratlscqssqsvynnnylswfqqkpgqpprlliygastltsgvp
drfsgsgsgtdftltisrlepedfavyycaggysgssdkyafgggtkveikrtvaapsvf
ifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysls
stltlskadyekhkvyacevthqglsspvtksfnrg

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6xm2D (D:)
eqqlqesgpglvkpsetlsltctvtgfslssytvnwvrqpagkglewigyisyggsayya
swangrftiskdssknqvslklssvtaadtavyfcarhmqvggaptgsmaafdpwgpgtl
vtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpa
vlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdktht

    Sequence, based on observed residues (ATOM records): (download) 
    >6xm2D (D:)
qqlqesgpglvkpsetlsltctvtgfslssytvnwvrqpagkglewigyisyggsayyas
wangrftiskdssknqvslklssvtaadtavyfcarhmqvggaptgsmaafdpwgpgtlv
tvssastkgpsvfplaptaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglys
lssvvtvpssslgtqtyicnvnhkpsntkvdkkvep

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6xm2E (E:)
eavltqspgtlslspgeratlscqssqsvynnnylswfqqkpgqpprlliygastltsgv
pdrfsgsgsgtdftltisrlepedfavyycaggysgssdkyafgggtkveikrtvaapsv
fifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysl
sstltlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >6xm2E (E:)
avltqspgtlslspgeratlscqssqsvynnnylswfqqkpgqpprlliygastltsgvp
drfsgsgsgtdftltisrlepedfavyycaggysgssdkyafgggtkveikrtvaapsvf
ifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysls
stltlskadyekhkvyacevthqglsspvtksfnrgec

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6xm2F (F:)
eqqlqesgpglvkpsetlsltctvtgfslssytvnwvrqpagkglewigyisyggsayya
swangrftiskdssknqvslklssvtaadtavyfcarhmqvggaptgsmaafdpwgpgtl
vtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpa
vlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdktht

    Sequence, based on observed residues (ATOM records): (download) 
    >6xm2F (F:)
qqlqesgpglvkpsetlsltctvtgfslssytvnwvrqpagkglewigyisyggsayyas
wangrftiskdssknqvslklssvtaadtavyfcarhmqvggaptgsmaafdpwgpgtlv
tvssastkgpsvfplapssaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgly
slssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscd

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >6xm2G (G:)
eavltqspgtlslspgeratlscqssqsvynnnylswfqqkpgqpprlliygastltsgv
pdrfsgsgsgtdftltisrlepedfavyycaggysgssdkyafgggtkveikrtvaapsv
fifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysl
sstltlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >6xm2G (G:)
eavltqspgtlslspgeratlscqssqsvynnnylswfqqkpgqpprlliygastltsgv
pdrfsgsgsgtdftltisrlepedfavyycaggysgssdkyafgggtkveikrtvaapsv
fifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysl
sstltlskadyekhkvyacevthqglsspvtksfnrge

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6xm2H (H:)
eqqlqesgpglvkpsetlsltctvtgfslssytvnwvrqpagkglewigyisyggsayya
swangrftiskdssknqvslklssvtaadtavyfcarhmqvggaptgsmaafdpwgpgtl
vtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpa
vlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdktht

    Sequence, based on observed residues (ATOM records): (download) 
    >6xm2H (H:)
qqlqesgpglvkpsetlsltctvtgfslssytvnwvrqpagkglewigyisyggsayyas
wangrftiskdssknqvslklssvtaadtavyfcarhmqvggaptgsmaafdpwgpgtlv
tvssastkgpsvfplapstaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgly
slssvvtvpssslgtqtyicnvnhkpsntkvdkkvep

  • Chain 'I':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6xm2I (I:)
aldaaycfrnvqdncclrplyidfkrdlgwkwihepkgynanfcagacpylwssdtqhsr
vlslyntinpeasaspccvsqdlepltilyyigktpkieqlsnmivksckcs

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >6xm2J (J:)
aldaaycfrnvqdncclrplyidfkrdlgwkwihepkgynanfcagacpylwssdtqhsr
vlslyntinpeasaspccvsqdlepltilyyigktpkieqlsnmivksckcs

    Sequence, based on observed residues (ATOM records): (download) 
    >6xm2J (J:)
aldaaycfrnvqdncclrplyidfkrdlgwkwihepkgynanfcagacpwdtqhsrvlsl
yntinpeasaspccvsqdlepltilyyigktpkieqlsnmivksckcs

  • Chain 'K':
    Sequence, based on SEQRES records: (download) 
    >6xm2K (K:)
aldaaycfrnvqdncclrplyidfkrdlgwkwihepkgynanfcagacpylwssdtqhsr
vlslyntinpeasaspccvsqdlepltilyyigktpkieqlsnmivksckcs

    Sequence, based on observed residues (ATOM records): (download) 
    >6xm2K (K:)
aldaaycfrnvqdncclrplyidfkrdlgwkwihepkgynanfcagacptqhsrvlslyn
tinpeasaspccvsqdlepltilyyigktpkieqlsnmivksckcs

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >6xm2L (L:)
aldaaycfrnvqdncclrplyidfkrdlgwkwihepkgynanfcagacpylwssdtqhsr
vlslyntinpeasaspccvsqdlepltilyyigktpkieqlsnmivksckcs

    Sequence, based on observed residues (ATOM records): (download) 
    >6xm2L (L:)
aldaaycfrnvqdncclrplyidfkrdlgwkwihepkgynanfcagacpwsdtqhsrvls
lyntinpeasaspccvsqdlepltilyyigktpkieqlsnmivksckcs