PDB entry 6vpf

View 6vpf on RCSB PDB site
Description: Estrogen Receptor Alpha Ligand Binding Domain in Complex with the Selective Estrogen Receptor Modulator Clomiphene
Class: transferase
Keywords: Breast Cancer, Hormone, Selective Estrogen Receptor Modulator, Antiestrogen, Alpha Helical Bundle, TRANSFERASE
Deposited on 2020-02-03, released 2020-09-16
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-09-16, with a file datestamp of 2020-09-11.
Experiment type: XRAY
Resolution: 1.6 Å
R-factor: N/A
AEROSPACI score: 0.53 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • conflict (89)
      • conflict (125)
      • conflict (238)
      • conflict (244)
    Domains in SCOPe 2.08: d6vpfa_
  • Chain 'B':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372 (14-End)
      • conflict (89)
      • conflict (125)
      • conflict (244)
    Domains in SCOPe 2.08: d6vpfb_
  • Chain 'C':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372 (14-End)
      • conflict (89)
      • conflict (125)
      • conflict (238)
      • conflict (244)
    Domains in SCOPe 2.08: d6vpfc_
  • Chain 'D':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • conflict (89)
      • conflict (125)
      • conflict (238)
      • conflict (244)
    Domains in SCOPe 2.08: d6vpfd_
  • Heterogens: 53Q, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6vpfA (A:)
hhhhhhenlyfqsmlalsltadqmvsalldaeppilyseydptrpfseasmmglltnlad
relvhminwakrvpgfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllld
rnqgksvegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlkslee
kdhihrvldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksk
nvvpsydlllemldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >6vpfA (A:)
alsltadqmvsalldaeppilyseydptrpfsasmmglltnladrelvhminwakrvpgf
vdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveifdm
llatssrfrmmnlqgeefvclksiillnsgvytfstlksleekdhihrvldkitdtlihl
makagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvpsydlllemld

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6vpfB (B:)
hhhhhhenlyfqsmlalsltadqmvsalldaeppilyseydptrpfseasmmglltnlad
relvhminwakrvpgfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllld
rnqgksvegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlkslee
kdhihrvldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksk
nvvpsydlllemldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >6vpfB (B:)
lalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvp
gfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveif
dmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdt
lihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkknvvpsydlllemlda
hrl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6vpfC (C:)
hhhhhhenlyfqsmlalsltadqmvsalldaeppilyseydptrpfseasmmglltnlad
relvhminwakrvpgfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllld
rnqgksvegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlkslee
kdhihrvldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksk
nvvpsydlllemldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >6vpfC (C:)
lalsltadqmvsalldaeppilyseydptrpfssmmglltnladrelvhminwakrvpgf
vdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveifdm
llatssrfrmmnlqgeefvclksiillnsgvytfstlksleekdhihrvldkitdtlihl
makagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvpsydlllemlda

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6vpfD (D:)
hhhhhhenlyfqsmlalsltadqmvsalldaeppilyseydptrpfseasmmglltnlad
relvhminwakrvpgfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllld
rnqgksvegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlkslee
kdhihrvldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksk
nvvpsydlllemldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >6vpfD (D:)
alsltadqmvsalldaeppilyseydptrpfsmmglltnladrelvhminwakrvpgfvd
ltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveifdmll
atssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdtlihl
makagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvpsydlllemld