PDB entry 6tz7

View 6tz7 on RCSB PDB site
Description: Crystal Structure of Aspergillus fumigatus Calcineurin A, Calcineurin B, FKBP12 and FK506 (Tacrolimus)
Class: Hydrolase/Isomerase/Calcium Binding
Keywords: Calcineurin, FK506, Hydrolase-Isomerase-Calcium Binding complex
Deposited on 2017-11-11, released 2019-09-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-10-02, with a file datestamp of 2019-09-27.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein phosphatase 2B catalytic subunit
    Species: Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) [TaxId:330879]
    Gene: cnaA, AFUA_5G09360
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6tz7a_
  • Chain 'B':
    Compound: Calcineurin Ca2+-binding regulatory subunit CnaB
    Species: Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) [TaxId:330879]
    Gene: AFUA_6G04540
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6tz7b_
  • Chain 'C':
    Compound: FK506-binding protein 1A
    Species: Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) [TaxId:330879]
    Gene: fpr1A, AFUA_6G12170
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q4WLV6 (16-126)
      • expression tag (10-15)
    Domains in SCOPe 2.08: d6tz7c1, d6tz7c2
  • Heterogens: FK5, ZN, FE, PO4, EDO, CA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6tz7A (A:)
mgsshhhhhhssglvprgsedgtqvstlervikevqapalstptdemfwspedpskpnlq
flkqhfyregrlteeqalwiihagtqilrsepnllemdapitvcgdvhgqyydlmklfev
ggdpsetrylflgdyvdrgyfsiecvlylwalkiwypnslwllrgnhecrhltdyftfkl
eckhkyseriyeaciesfcalplaavmnkqflcihgglspelhtlediksidrfreppth
glmcdilwadpleefgqektgdyfvhnsvrgcsyffsypaacafleknnllsiiraheaq
dagyrmyrktrttgfpsvmtifsapnyldvynnkaavlkyennvmnirqfnctphpywlp
nfmdvftwslpfvgekitdmliailntc

    Sequence, based on observed residues (ATOM records): (download) 
    >6tz7A (A:)
tlervikevqapalstptdemfwspedpskpnlqflkqhfyregrlteeqalwiihagtq
ilrsepnllemdapitvcgdvhgqyydlmklfevggdpsetrylflgdyvdrgyfsiecv
lylwalkiwypnslwllrgnhecrhltdyftfkleckhkyseriyeaciesfcalplaav
mnkqflcihgglspelhtlediksidrfreppthglmcdilwadpleefgqektgdyfvh
nsvrgcsyffsypaacafleknnllsiiraheaqdagyrmyrktrttgfpsvmtifsapn
yldvynnkaavlkyennvmnirqfnctphpywlpnfmdvftwslpfvgekitdmliai

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6tz7B (B:)
msvgtsqlldnivsasnfdrdevdrlrkrfmkldkdssgtidrdeflslpqvssnplatr
miaifdedgggdvdfqefvsglsafsskgnkeeklrfafkvydidrdgyisngelfivlk
mmvgnnlkdvqlqqivdktimeadkdrdgkisfeeftemventdvslsmtlsmf

    Sequence, based on observed residues (ATOM records): (download) 
    >6tz7B (B:)
evdrlrkrfmklsnplatrmiaifdedgggdvdfqefvsglsafskeeklrfafkvydid
rdgyisngelfivlkmmvgnnlkdvqlqqivdktimeadkdrdgkisfeeftemventsm
tl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6tz7C (C:)
mglndifeaqkiewhegvtkelkspgngvdfpkkgdfvtihytgrltdgskfdssvdrne
pfqtqigtgrvikgwdegvpqmslgekavltitpdygygargfppvipgnstlifevell
ginnkra

    Sequence, based on observed residues (ATOM records): (download) 
    >6tz7C (C:)
kiewhegvtkelkspgngvdfpkkgdfvtihytgrltdgskfdssvdrnepfqtqigtgr
vikgwdegvpqmslgekavltitpdygygargfppvipgnstlifevellginnkra