PDB entry 6t3b

View 6t3b on RCSB PDB site
Description: Crystal structure of PI3Kgamma with a dihydropurinone inhibitor (compound 4)
Class: transferase
Keywords: kinase fold, PI3 kinase, type I kinase inhibitor, TRANSFERASE
Deposited on 2019-10-10, released 2020-01-01
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-04-22, with a file datestamp of 2020-04-17.
Experiment type: XRAY
Resolution: 3.01 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PIK3CG
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6t3ba1, d6t3ba2, d6t3ba3
  • Heterogens: M9T

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6t3bA (A:)
mseesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwv
tskplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakkkslmdip
esqseqdfvlrvcgrdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrkee
wplvddctgvtgyheqltihgkdhesvftvslwdcdrkfrvkirgidipvlprntdltvf
veaniqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgallnlqiycgkapals
skasaespsseskgkvqllyyvnlllidhrfllrrgeyvlhmwqisgkgedqgsfnadkl
tsatnpdkensmsisilldnychpialpkhqptpdpegdrvraempnqlrkqleaiiatd
plnpltaedkellwhfryeslkhpkaypklfssvkwgqqeivaktyqllarrevwdqsal
dvgltmqlldcnfsdenvraiavqklesledddvlhyllqlvqavkfepyhdsalarfll
krglrnkrighflfwflrseiaqsrhyqqrfavileaylrgcgtamlhdftqqvqvieml
qkvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrvpydpglkagalaiekck
vmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilrimesiwetesldl
cllpygcistgdkigmieivkdattiakiqqstvgntgafkdevlnhwlkekspteekfq
aaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfghilgnyksflginker
vpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtgmpql
tskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhlvlgikqgekhsa
hhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6t3bA (A:)
esqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvtsk
plpeylwkkianncifivihrttsqtikvspddtpgailqdfvlrvcgrdeylvgetpik
nfqwvrhclkngeeihvvldtppdpaldevrkvslwdcdrkfrvkirgidipvtvfvean
iqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgallnlqiycqllyyvnllli
dhrfllrrgeyvlhmwqisfnadkltsatnpdkensmsisilldnychpialpkraempn
qlrkqleaiiatdplnpltaedkellwhfryeslkhpkaypklfssvkwgqqeivaktyq
llarrevwdqsaldvgltmqlldcnfsdenvraiavqklesledddvlhyllqlvqavkf
epyhdsalarfllkrglrnkrighflfwflrseiaqsrhyqqrfavileaylrgcgtaml
hdftqqvqviemlqkvtldikslsassqvisqlkqklenlqnsqlpesfrvpydpglkag
alaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilrimesi
wetesldlcllpygcistgdkigmieivkdattiakiqqkdevlnhwlkekspteekfqa
averfvyscagycvatfvlgigdrhndnimitetgnlfhidfghervpfvltpdflfvmg
tsgtsphfqkfqdicvkaylalrhhtnlliilfsmmlmtgmkedieyirdaltvgkneed
akkyfldqievcrdkgwtvqfnwf