PDB entry 6sua

View 6sua on RCSB PDB site
Description: Structure of the high affinity engineered lipocalin C1B12 in complex with the mouse CD98 heavy chain ectodomain
Class: protein binding
Keywords: Lipocalin, Lcn2, Anticalin, lipocalin-based binding protein, CD98hc, 4F2hc, amino acid transport, presentation of CD98 light chain, interaction with integrin beta subunit, single-pass type II membrane protein, PROTEIN BINDING
Deposited on 2019-09-13, released 2020-06-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-08-05, with a file datestamp of 2020-07-31.
Experiment type: XRAY
Resolution: 2.75 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Neutrophil gelatinase-associated lipocalin
    Species: Homo sapiens [TaxId:9606]
    Gene: LCN2, HNL, NGAL
    Database cross-references and differences (RAF-indexed):
    • Uniprot P80188 (Start-177)
      • engineered mutation (27)
      • engineered mutation (39-40)
      • engineered mutation (48)
      • engineered mutation (67)
      • engineered mutation (71-72)
      • engineered mutation (76)
      • engineered mutation (78)
      • engineered mutation (80)
      • engineered mutation (86)
      • engineered mutation (95)
      • engineered mutation (99-100)
      • engineered mutation (102)
      • engineered mutation (105)
      • engineered mutation (124)
      • engineered mutation (126)
      • engineered mutation (131)
      • engineered mutation (133)
    Domains in SCOPe 2.08: d6suaa_
  • Chain 'B':
    Compound: 4F2 cell-surface antigen heavy chain
    Species: Mus musculus [TaxId:10090]
    Gene: SLC3A2, MDU1
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Neutrophil gelatinase-associated lipocalin
    Species: Homo sapiens [TaxId:9606]
    Gene: LCN2, HNL, NGAL
    Database cross-references and differences (RAF-indexed):
    • Uniprot P80188 (Start-177)
      • engineered mutation (27)
      • engineered mutation (39-40)
      • engineered mutation (48)
      • engineered mutation (67)
      • engineered mutation (71-72)
      • engineered mutation (76)
      • engineered mutation (78)
      • engineered mutation (80)
      • engineered mutation (86)
      • engineered mutation (95)
      • engineered mutation (99-100)
      • engineered mutation (102)
      • engineered mutation (105)
      • engineered mutation (124)
      • engineered mutation (126)
      • engineered mutation (131)
      • engineered mutation (133)
    Domains in SCOPe 2.08: d6suac_
  • Chain 'D':
    Compound: 4F2 cell-surface antigen heavy chain
    Species: Mus musculus [TaxId:10090]
    Gene: SLC3A2, MDU1
    Database cross-references and differences (RAF-indexed):
  • Heterogens: SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6suaA (A:)
qdstsdlipapplskvplqqnfqdnqfhgkwyvvglagngnlredkdplkmyatiyelke
dksynvtdvlfidkkchylintfvpgsqpgeftlgsikstlgstsrlvrvvstnynqham
vffkwvhqnrewfyitlygrtkeltselkenfirfskslglpenhivfpvpidqcidgsa
hhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6suaA (A:)
sdlipapplskvplqqnfqdnqfhgkwyvvglagngnlredkdplkmyatiyelkedksy
nvtdvlfidkkchylintfvpgsqpgeftlgsikstlgstsrlvrvvstnynqhamvffk
wvhqnrewfyitlygrtkeltselkenfirfskslglpenhivfpvpidqcidg

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6suaC (C:)
qdstsdlipapplskvplqqnfqdnqfhgkwyvvglagngnlredkdplkmyatiyelke
dksynvtdvlfidkkchylintfvpgsqpgeftlgsikstlgstsrlvrvvstnynqham
vffkwvhqnrewfyitlygrtkeltselkenfirfskslglpenhivfpvpidqcidgsa
hhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6suaC (C:)
sdlipapplskvplqqnfqdnqfhgkwyvvglagngnlredkdplkmyatiyelkedksy
nvtdvlfidkkchylintfvpgsqpgeftlgsikstlgstsrlvrvvstnynqhamvffk
wvhqnrewfyitlygrtkeltselkenfirfskslglpenhivfpvpidqcidg

  • Chain 'D':
    No sequence available.