PDB entry 6qxs

View 6qxs on RCSB PDB site
Description: Crystal structure of Enteroccocus faecalis thymidylate synthase (EfTS) in complex with FdUMP
Class: transferase
Keywords: Enteroccocus faecalis thymidylate synthase, EfTS, folate pathway, inhibitor, FdUMP, TRANSFERASE
Deposited on 2019-03-07, released 2019-04-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-11-20, with a file datestamp of 2019-11-15.
Experiment type: XRAY
Resolution: 2.88 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidylate synthase
    Species: Enterococcus faecalis (strain ATCC 700802 / V583) [TaxId:226185]
    Gene: thyA, EF_1576
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6qxsa_
  • Chain 'B':
    Compound: Thymidylate synthase
    Species: Enterococcus faecalis [TaxId:1351]
    Gene: thyA, EF_1576
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6qxsb_
  • Chain 'C':
    Compound: Thymidylate synthase
    Species: Enterococcus faecalis [TaxId:1351]
    Gene: thyA, EF_1576
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6qxsc_
  • Chain 'D':
    Compound: Thymidylate synthase
    Species: Enterococcus faecalis [TaxId:1351]
    Gene: thyA, EF_1576
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6qxsd_
  • Heterogens: UFP, SO4, FFO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6qxsA (A:)
meeaylalgkkileeghfkedrtgtgtyslfgyqmrfdlakgfpllttkrvpfgliksel
lwflkgdtniryllernnhiwdewaferyvksadyqgpdmtdfghrvlqdpafaeqykee
hqkfcdailndaefaekygelgniygaqwrhwetkdgsfidqlanviemiktnpdsrrli
vsawnpedvpsmalppchtmfqfyvnegklscqlyqrsadvflgvpfniasyallthlia
hetglevgefvhtlgdahlyqnhveqmqeqlsrevrsfptlvlnpdkasvfdfdmedikv
egydphptikapiav

    Sequence, based on observed residues (ATOM records): (download) 
    >6qxsA (A:)
meeaylalgkkileeghfkedrtgtgtyslfgyqmrfdlakgfpllttkrvpfgliksel
lwflkgdtniryllernnhiwdewaferyvksadyqgeehqkfcdailndaefaekygel
gniygaqwrhwetkdgsfidqlanviemiktnpdsrrlivsawnpedvpsmalppchtmf
qfyvnegklscqlyqrsadvflgvpfniasyallthliahetglevgefvhtlgdahlyq
nhveqmqeqlsrevrsfptlvlnpdkasvfdfdmedikvegydphptikapi

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6qxsB (B:)
meeaylalgkkileeghfkedrtgtgtyslfgyqmrfdlakgfpllttkrvpfgliksel
lwflkgdtniryllernnhiwdewaferyvksadyqgpdmtdfghrvlqdpafaeqykee
hqkfcdailndaefaekygelgniygaqwrhwetkdgsfidqlanviemiktnpdsrrli
vsawnpedvpsmalppchtmfqfyvnegklscqlyqrsadvflgvpfniasyallthlia
hetglevgefvhtlgdahlyqnhveqmqeqlsrevrsfptlvlnpdkasvfdfdmedikv
egydphptikapiav

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6qxsC (C:)
meeaylalgkkileeghfkedrtgtgtyslfgyqmrfdlakgfpllttkrvpfgliksel
lwflkgdtniryllernnhiwdewaferyvksadyqgpdmtdfghrvlqdpafaeqykee
hqkfcdailndaefaekygelgniygaqwrhwetkdgsfidqlanviemiktnpdsrrli
vsawnpedvpsmalppchtmfqfyvnegklscqlyqrsadvflgvpfniasyallthlia
hetglevgefvhtlgdahlyqnhveqmqeqlsrevrsfptlvlnpdkasvfdfdmedikv
egydphptikapiav

    Sequence, based on observed residues (ATOM records): (download) 
    >6qxsC (C:)
meeaylalgkkileeghfkedrtgtgtyslfgyqmrfdlakgfpllttkrvpfgliksel
lwflkgdtniryllernnhiwdewaferyvksadyqgeehqkfcdailndaefaekygel
gniygaqwrhwetkdgsfidqlanviemiktnpdsrrlivsawnpedvpsmalppchtmf
qfyvnegklscqlyqrsadvflgvpfniasyallthliahetglevgefvhtlgdahlyq
nhveqmqeqlsrevrsfptlvlnpdkasvfdfdmedikvegydphptikapi

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6qxsD (D:)
meeaylalgkkileeghfkedrtgtgtyslfgyqmrfdlakgfpllttkrvpfgliksel
lwflkgdtniryllernnhiwdewaferyvksadyqgpdmtdfghrvlqdpafaeqykee
hqkfcdailndaefaekygelgniygaqwrhwetkdgsfidqlanviemiktnpdsrrli
vsawnpedvpsmalppchtmfqfyvnegklscqlyqrsadvflgvpfniasyallthlia
hetglevgefvhtlgdahlyqnhveqmqeqlsrevrsfptlvlnpdkasvfdfdmedikv
egydphptikapiav