PDB entry 6q8z

View 6q8z on RCSB PDB site
Description: Structure of human galactokinase 1 bound with N-(Cyclobutylmethyl)-1,5-dimethyl-1H-pyrazole-4-carboxamide
Class: transferase
Keywords: GALK1, fragment, fragment-bound, galactokinase 1, sugar kinase, TRANSFERASE
Deposited on 2018-12-16, released 2019-01-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-06-29.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Galactokinase
    Species: Homo sapiens [TaxId:9606]
    Gene: GALK1, GALK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51570 (1-391)
      • expression tag (0)
    Domains in SCOPe 2.08: d6q8za1, d6q8za2, d6q8za3
  • Chain 'B':
    Compound: Galactokinase
    Species: Homo sapiens [TaxId:9606]
    Gene: GALK1, GALK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6q8zb1, d6q8zb2
  • Chain 'C':
    Compound: Galactokinase
    Species: Homo sapiens [TaxId:9606]
    Gene: GALK1, GALK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6q8zc1, d6q8zc2
  • Chain 'D':
    Compound: Galactokinase
    Species: Homo sapiens [TaxId:9606]
    Gene: GALK1, GALK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6q8zd1, d6q8zd2
  • Heterogens: GAL, HFK, HR5, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6q8zA (A:)
haalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvlpmalelm
tvlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgviqyypaa
plpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqaehsfagm
pcgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhslasseypvrr
rqceevaralgkeslrevqleeleaardlvskegfrrarhvvgeirrtaqaaaalrrgdy
rafgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctvtlleasa
aphamrhiqehyggtatfylsqaadgakvlcl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6q8zB (B:)
haalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvlpmalelm
tvlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgviqyypaa
plpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqaehsfagm
pcgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhslasseypvrr
rqceevaralgkeslrevqleeleaardlvskegfrrarhvvgeirrtaqaaaalrrgdy
rafgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctvtlleasa
aphamrhiqehyggtatfylsqaadgakvlcl

    Sequence, based on observed residues (ATOM records): (download) 
    >6q8zB (B:)
alrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvlpmalelmtv
lvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgviqyypaapl
pgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqaehsfagmpc
gimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhslasseypvrrrq
ceevaralgkeslrevqleeleaardlvkegfrrarhvvgeirrtaqaaaalrrgdyraf
grlmveshrslrddyevscpeldqlvaalavpgvygsrmtgggfggctvtlleasaapha
mrhqehyggtatfylsqaadgakvlcl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6q8zC (C:)
haalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvlpmalelm
tvlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgviqyypaa
plpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqaehsfagm
pcgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhslasseypvrr
rqceevaralgkeslrevqleeleaardlvskegfrrarhvvgeirrtaqaaaalrrgdy
rafgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctvtlleasa
aphamrhiqehyggtatfylsqaadgakvlcl

    Sequence, based on observed residues (ATOM records): (download) 
    >6q8zC (C:)
alrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvlpmalelmtv
lvgsprlvsllttsegadepqrlqfplptaqrslepgtprwanyvkgviqyypaaplpgf
savvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqaehsfagmpcgim
dqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhslaseypvrrrqceev
aralgkeslrevqleeleaardlvskegfrrarhvvgeirrtaqaaaalrrgdyrafgrl
mveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctvtlleasaaphamr
hiqehyggtatfylsqaadgakvlcl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6q8zD (D:)
haalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvlpmalelm
tvlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgviqyypaa
plpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqaehsfagm
pcgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhslasseypvrr
rqceevaralgkeslrevqleeleaardlvskegfrrarhvvgeirrtaqaaaalrrgdy
rafgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctvtlleasa
aphamrhiqehyggtatfylsqaadgakvlcl

    Sequence, based on observed residues (ATOM records): (download) 
    >6q8zD (D:)
qvaellaearrafreefgaepelavsapgrvnligehtdynqglvlpmalelmtvlvgsp
rkdglvsllttsdepqrlqfplptaqrslepgtprwanyvkgviqyypaaplpgfsavvv
ssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqaehsfamdqfislmgqkg
hallidcrsletslvplsdpklavlitnsnvrhslasseypvrrrqceevaralgkeslr
evqleeleaardlvskegfrrarhvvgeirrtaqaaaalrrgdyrafgrlmveshrslrd
dyevscpeldqlveaalavpgvygsrmtgggfggctvtlleasaaphamrhiqehyggta
tfylsqaadgakvlcl