PDB entry 6piz

View 6piz on RCSB PDB site
Description: Crystal structure of HCV NS3/4A D168A protease in complex with P4-1 (NR02-24)
Class: hydrolase/hydrolase inhibitor
Keywords: NS3/4a Protease, Hepatitis C virus, Drug Resistance, Protease inhibitor, HYDROLASE-HYDROLASE Inhibitor complex, HYDROLASE
Deposited on 2019-06-27, released 2020-03-04
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-09-16, with a file datestamp of 2020-09-11.
Experiment type: XRAY
Resolution: 1.89 Å
R-factor: N/A
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: NS3/4A protease
    Species: Hepacivirus C [TaxId:11103]
    Database cross-references and differences (RAF-indexed):
    • Uniprot A0A0B4WYC6 (42-End)
      • expression tag (20-41)
      • conflict (51-52)
      • conflict (55-56)
      • conflict (59)
      • conflict (85)
      • conflict (90)
      • conflict (110)
      • conflict (124)
      • conflict (197)
      • engineered mutation (206)
    Domains in SCOPe 2.08: d6piza1, d6piza2
  • Heterogens: SO4, ON4, GOL, EDO, ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6pizA (A:)
mgsshhhhhhssglvprgshhmasmkkkgsvvivgrinlsgdtayaqqtrgeegcqetsq
tgrdknqvegevqivstatqtflatsingvlwtvyhgagtrtiaspkgpvtqmytnvdkd
lvgwqapqgsrsltpctcgssdlylvtrhadvipvrrrgdsrgsllsprpisylkgssgg
pllcpaghavgifraavstrgvakavafipveslettmrsp

    Sequence, based on observed residues (ATOM records): (download) 
    >6pizA (A:)
hmasmkkkgsvvivgrinlsgdtayaqqtrgeegcqetsqtgrdknqvegevqivstatq
tflatsingvlwtvyhgagtrtiaspkgpvtqmytnvdkdlvgwqapqgsrsltpctcgs
sdlylvtrhadvipvrrrgdsrgsllsprpisylkgssggpllcpaghavgifraavstr
gvakavafipveslettm