PDB entry 6peb

View 6peb on RCSB PDB site
Description: Crystal Structure of human NAMPT in complex with NVP-LTM976
Class: transferase
Keywords: transferase
Deposited on 2019-06-20, released 2019-12-04
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-04, with a file datestamp of 2019-11-29.
Experiment type: XRAY
Resolution: 2.46 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Nicotinamide phosphoribosyltransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: NAMPT, PBEF, PBEF1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6peba1, d6peba2
  • Chain 'B':
    Compound: Nicotinamide phosphoribosyltransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: NAMPT, PBEF, PBEF1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6pebb1, d6pebb2
  • Chain 'C':
    Compound: Nicotinamide phosphoribosyltransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: NAMPT, PBEF, PBEF1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6pebc1, d6pebc2
  • Chain 'D':
    Compound: Nicotinamide phosphoribosyltransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: NAMPT, PBEF, PBEF1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6pebd1, d6pebd2
  • Heterogens: OE4, PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6pebA (A:)
npaaeaefnillatdsykvthykqyppntskvysyfecrekktensklrkvkyeetvfyg
lqyilnkylkgkvvtkekiqeakdvykehfqddvfnekgwnyilekydghlpieikavpe
gfviprgnvlftventdpecywltnwietilvqswypitvatnsreqkkilakylletsg
nldgleyklhdfgyrgvssqetagigasahlvnfkgtdtvaglalikkyygtkdpvpgys
vpaaehstitawgkdhekdafehivtqfssvpvsvvsdsydiynacekiwgedlrhlivs
rstqapliirpdsgnpldtvlkvleilgkkfpvtenskgykllppylrviqgdgvdintl
qeivegmkqkmwsieniafgsgggllqkltrdllncsfkcsyvvtnglginvfkdpvadp
nkrskkgrlslhrtpagnfvtleegkgdleeygqdllhtvfkngkvtksysfdeirknaq
lnieleaahhlehhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6pebA (A:)
efnillatdsykvthykqyppntskvysyfecrekkvkyeetvfyglqyilnkylkgkvv
tkekiqeakdvykehfqddvfnekgwnyilekydghlpieikavpegfviprgnvlftve
ntdpecywltnwietilvqswypitvatnsreqkkilakylletsgnldgleyklhdfgy
rgvssqetagigasahlvnfkgtdtvaglalikkyygtkdpvpgysvpaaehstitawgk
dhekdafehivtqfssvpvsvvsdsydiynacekiwgedlrhlivsrstqapliirpdsg
npldtvlkvleilgkkfpvtenskgykllppylrviqgdgvdintlqeivegmkqkmwsi
eniafgsgggllqkltrdllncsfkcsyvvtnglginvfkdpvadpnkrskkgrlslhrt
pagnfvtleegkgdleeygqdllhtvfkngkvtksysfdeirknaqlni

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6pebB (B:)
npaaeaefnillatdsykvthykqyppntskvysyfecrekktensklrkvkyeetvfyg
lqyilnkylkgkvvtkekiqeakdvykehfqddvfnekgwnyilekydghlpieikavpe
gfviprgnvlftventdpecywltnwietilvqswypitvatnsreqkkilakylletsg
nldgleyklhdfgyrgvssqetagigasahlvnfkgtdtvaglalikkyygtkdpvpgys
vpaaehstitawgkdhekdafehivtqfssvpvsvvsdsydiynacekiwgedlrhlivs
rstqapliirpdsgnpldtvlkvleilgkkfpvtenskgykllppylrviqgdgvdintl
qeivegmkqkmwsieniafgsgggllqkltrdllncsfkcsyvvtnglginvfkdpvadp
nkrskkgrlslhrtpagnfvtleegkgdleeygqdllhtvfkngkvtksysfdeirknaq
lnieleaahhlehhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6pebB (B:)
aefnillatdsykvthykqyppntskvysyfecrekkyeetvfyglqyilnkylkgkvvt
kekiqeakdvykehfqddvfnekgwnyilekydghlpieikavpegfviprgnvlftven
tdpecywltnwietilvqswypitvatnsreqkkilakylletsgnldgleyklhdfgyr
gvssqetagigasahlvnfkgtdtvaglalikkyygtkdpvpgysvpaaehstitawgkd
hekdafehivtqfssvpvsvvsdsydiynacekiwgedlrhlivsrstqapliirpdsgn
pldtvlkvleilgkkfpvtenskgykllppylrviqgdgvdintlqeivegmkqkmwsie
niafgsgggllqkltrdllncsfkcsyvvtnglginvfkdpvadpnkrskkgrlslhrtp
agnfvtleegkgdleeygqdllhtvfkngkvtksysfdeirknaqlni

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6pebC (C:)
npaaeaefnillatdsykvthykqyppntskvysyfecrekktensklrkvkyeetvfyg
lqyilnkylkgkvvtkekiqeakdvykehfqddvfnekgwnyilekydghlpieikavpe
gfviprgnvlftventdpecywltnwietilvqswypitvatnsreqkkilakylletsg
nldgleyklhdfgyrgvssqetagigasahlvnfkgtdtvaglalikkyygtkdpvpgys
vpaaehstitawgkdhekdafehivtqfssvpvsvvsdsydiynacekiwgedlrhlivs
rstqapliirpdsgnpldtvlkvleilgkkfpvtenskgykllppylrviqgdgvdintl
qeivegmkqkmwsieniafgsgggllqkltrdllncsfkcsyvvtnglginvfkdpvadp
nkrskkgrlslhrtpagnfvtleegkgdleeygqdllhtvfkngkvtksysfdeirknaq
lnieleaahhlehhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6pebC (C:)
efnillatdsykvthykqyppntskvysyfecrekvkyeetvfyglqyilnkylkgkvvt
kekiqeakdvykehfqddvfnekgwnyilekydghlpieikavpegfviprgnvlftven
tdpecywltnwietilvqswypitvatnsreqkkilakylletsgnldgleyklhdfgyr
gvssqetagigasahlvnfkgtdtvaglalikkyygtkdpvpgysvpaaehstitawgkd
hekdafehivtqfssvpvsvvsdsydiynacekiwgedlrhlivsrstqapliirpdsgn
pldtvlkvleilgkkfpvtenskgykllppylrviqgdgvdintlqeivegmkqkmwsie
niafgsgggllqkltrdllncsfkcsyvvtnglginvfkdpvadpnkrskkgrlslhrtp
agnfvtleegkgdleeygqdllhtvfkngkvtksysfdeirknaqlnie

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6pebD (D:)
npaaeaefnillatdsykvthykqyppntskvysyfecrekktensklrkvkyeetvfyg
lqyilnkylkgkvvtkekiqeakdvykehfqddvfnekgwnyilekydghlpieikavpe
gfviprgnvlftventdpecywltnwietilvqswypitvatnsreqkkilakylletsg
nldgleyklhdfgyrgvssqetagigasahlvnfkgtdtvaglalikkyygtkdpvpgys
vpaaehstitawgkdhekdafehivtqfssvpvsvvsdsydiynacekiwgedlrhlivs
rstqapliirpdsgnpldtvlkvleilgkkfpvtenskgykllppylrviqgdgvdintl
qeivegmkqkmwsieniafgsgggllqkltrdllncsfkcsyvvtnglginvfkdpvadp
nkrskkgrlslhrtpagnfvtleegkgdleeygqdllhtvfkngkvtksysfdeirknaq
lnieleaahhlehhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6pebD (D:)
aefnillatdsykvthykqyppntskvysyfecrekktekyeetvfyglqyilnkylkgk
vvtkekiqeakdvykehfqddvfnekgwnyilekydghlpieikavpegfviprgnvlft
ventdpecywltnwietilvqswypitvatnsreqkkilakylletsgnldgleyklhdf
gyrgvssqetagigasahlvnfkgtdtvaglalikkyygtkdpvpgysvpaaehstitaw
gkdhekdafehivtqfssvpvsvvsdsydiynacekiwgedlrhlivsrstqapliirpd
sgnpldtvlkvleilgkkfpvtenskgykllppylrviqgdgvdintlqeivegmkqkmw
sieniafgsgggllqkltrdllncsfkcsyvvtnglginvfkdpvadpnkrskkgrlslh
rtpagnfvtleegkgdleeygqdllhtvfkngkvtksysfdeirknaqlni