PDB entry 6owc

View 6owc on RCSB PDB site
Description: Mutant estrogen receptor alpha (ERa) Y537S covalently bound to H3B-6545.
Class: Transcription/transcription inhibitor
Keywords: Nuclear Hormone Receptor, H3B-6545, Inhibitor, SERM, TRANSCRIPTION, Transcription-transcription inhibitor complex
Deposited on 2019-05-09, released 2019-06-19
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-06-19, with a file datestamp of 2019-06-14.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: N/A
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • engineered mutation (120)
      • engineered mutation (240)
    Domains in SCOPe 2.08: d6owca_
  • Chain 'B':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • engineered mutation (120)
      • engineered mutation (240)
    Domains in SCOPe 2.08: d6owcb_
  • Heterogens: ND1, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6owcA (A:)
gikrskknslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvh
minwakrvpgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgk
svegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhih
rvldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvpl
sdlllemldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >6owcA (A:)
slalsltadqmvsalldaeppilyseydppfseasmmglltnladrelvhminwakrvpg
fvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveifd
mllatssrfrmmnlqgeefvclksiillnsgvytleekdhihrvldkitdtlihlmakag
ltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvplsdlllemlda

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6owcB (B:)
gikrskknslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvh
minwakrvpgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgk
svegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhih
rvldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvpl
sdlllemldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >6owcB (B:)
rskknslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhmin
wakrvpgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgksve
gmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvl
dkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcksdllleml
da