PDB entry 6oa3

View 6oa3 on RCSB PDB site
Description: Structure of human PARG complexed with JA2131
Class: hydrolase/hydrolase inhibitor
Keywords: HYDROLASE, hydrolase-hydrolase inhibitor complex
Deposited on 2019-03-15, released 2019-12-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-25, with a file datestamp of 2019-12-20.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Poly(ADP-ribose) glycohydrolase
    Species: Homo sapiens [TaxId:9606]
    Gene: parG
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q86W56
      • engineered mutation (172-174)
      • engineered mutation (244-246)
    Domains in SCOPe 2.08: d6oa3a_
  • Heterogens: M0M, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6oa3A (A:)
gphmspdkkwlgtpieemrrmprcgirlpllrpsanhtvtirvdllragevpkpfpthyk
dlwdnkhvkmpcseqnlypvedengertagsrweliqtallnkftrpqnlkdailkynva
yskkwdftalidfwdkvleeaeaqhlyqsilpdmvkialclpnictqpipllaaamnhsi
tmsqeqiasllanaffctfprrnakmkseyssypdinfnrlfegrssrkpeklktlfcyf
rrvtaaaptglvtftrqsledfpewercekpltrlhvtyegtieengqgmlqvdfanrfv
gggvtsaglvqeeirflinpeliisrlftevldhnecliitgteqyseytgyaetyrwsr
shedgserddwqrrcteivaidalhfrryldqfvpekmrrelnkaycgflrpgvssenls
avatgnwgcgafggdarlkaliqilaaaaaerdvvyftfgdselmrdiysmhiflterkl
tvgdvyklllryyneecrncstpgpdiklypfiyhavescaetadhsgqrtgt

    Sequence, based on observed residues (ATOM records): (download) 
    >6oa3A (A:)
dkkwlgtpieemrrmprcgirlpllrpsanhtvtirvdllragevpkpfpthykdlwdnk
hvkmpcseqnlypvtagsrweliqtallnkftrpqnlkdailkynvayskkwdftalidf
wdkvleeaeaqhlyqsilpdmvkialclpnictqpipllaaamnhsitmsqeqiasllan
affctfprrnssypdinfnrlfegrssrkpeklktlfcyfrrvtaaaptglvtftrqsle
dfpewercekpltrlhvtyegtieengqgmlqvdfanrfvgggvtsaglvqeeirflinp
eliisrlftevldhnecliitgteqyseytgyaetyrwsrshedgserddwqrrcteiva
idalhfrryldqfvpekmrrelnkaycgflrpgvssenlsavatgnwgcgafggdarlka
liqilaaaaaerdvvyftfgdselmrdiysmhiflterkltvgdvyklllryyneecrnc
stpgpdiklypfiyhavesc