SCOPe 2.08: Structural Classification of Proteins

PDB entry 6fxn

View 6fxn on RCSB PDB site
Description: Crystal structure of human BAFF in complex with Fab fragment of anti-BAFF antibody belimumab
Class: immune system
Keywords: Immunology, B cell, cytokine, BAFF, antibody, Proteros, IMMUNE SYSTEM
Deposited on 2018-03-09, released 2018-04-04
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-04-04, with a file datestamp of 2018-03-29.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: tumor necrosis factor ligand superfamily member 13b
Species: Homo sapiens [TaxId:9606]
Gene: TNFSF13B, BAFF, BLYS, TALL1, TNFSF20, ZTNF4, UNQ401/PRO738
Database cross-references and differences (RAF-indexed):
- Uniprot Q9Y275 (Start-163)
  - engineered mutation (96)
Domains in SCOPe 2.08: d6fxna_
Chain 'B':
Compound: tumor necrosis factor ligand superfamily member 13b
Species: Homo sapiens [TaxId:9606]
Gene: TNFSF13B, BAFF, BLYS, TALL1, TNFSF20, ZTNF4, UNQ401/PRO738
Database cross-references and differences (RAF-indexed):
- Uniprot Q9Y275 (Start-163)
  - engineered mutation (96)
Domains in SCOPe 2.08: d6fxnb_
Chain 'C':
Compound: tumor necrosis factor ligand superfamily member 13b
Species: Homo sapiens [TaxId:9606]
Gene: TNFSF13B, BAFF, BLYS, TALL1, TNFSF20, ZTNF4, UNQ401/PRO738
Database cross-references and differences (RAF-indexed):
- Uniprot Q9Y275 (Start-163)
  - engineered mutation (96)
Domains in SCOPe 2.08: d6fxnc_
Chain 'D':
Compound: belimumab heavy chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 6FXN (0-End)
Domains in SCOPe 2.08: d6fxnd1, d6fxnd2
Chain 'E':
Compound: belimumab light chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 6FXN
Domains in SCOPe 2.08: d6fxne1, d6fxne2
Chain 'F':
Compound: belimumab heavy chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 6FXN
Domains in SCOPe 2.08: d6fxnf1, d6fxnf2
Chain 'G':
Compound: belimumab light chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 6FXN
Domains in SCOPe 2.08: d6fxng1, d6fxng2
Chain 'H':
Compound: belimumab heavy chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 6FXN
Domains in SCOPe 2.08: d6fxnh1, d6fxnh2
Chain 'I':
Compound: belimumab light chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 6FXN
Domains in SCOPe 2.08: d6fxni1, d6fxni2
Chain 'J':
Compound: tumor necrosis factor ligand superfamily member 13b
Species: Homo sapiens [TaxId:9606]
Gene: TNFSF13B, BAFF, BLYS, TALL1, TNFSF20, ZTNF4, UNQ401/PRO738
Database cross-references and differences (RAF-indexed):
- Uniprot Q9Y275 (Start-163)
  - engineered mutation (96)
Domains in SCOPe 2.08: d6fxnj_
Chain 'K':
Compound: tumor necrosis factor ligand superfamily member 13b
Species: Homo sapiens [TaxId:9606]
Gene: TNFSF13B, BAFF, BLYS, TALL1, TNFSF20, ZTNF4, UNQ401/PRO738
Database cross-references and differences (RAF-indexed):
- Uniprot Q9Y275 (Start-163)
  - engineered mutation (96)
Domains in SCOPe 2.08: d6fxnk_
Chain 'L':
Compound: tumor necrosis factor ligand superfamily member 13b
Species: Homo sapiens [TaxId:9606]
Gene: TNFSF13B, BAFF, BLYS, TALL1, TNFSF20, ZTNF4, UNQ401/PRO738
Database cross-references and differences (RAF-indexed):
- Uniprot Q9Y275 (Start-163)
  - engineered mutation (96)
Domains in SCOPe 2.08: d6fxnl_
Chain 'M':
Compound: belimumab heavy chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 6FXN
Domains in SCOPe 2.08: d6fxnm1, d6fxnm2
Chain 'N':
Compound: belimumab light chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 6FXN
Domains in SCOPe 2.08: d6fxnn1, d6fxnn2
Chain 'O':
Compound: belimumab heavy chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 6FXN (0-End)
Domains in SCOPe 2.08: d6fxno1, d6fxno2
Chain 'P':
Compound: belimumab light chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 6FXN
Domains in SCOPe 2.08: d6fxnp1, d6fxnp2
Chain 'Q':
Compound: belimumab heavy chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 6FXN
Domains in SCOPe 2.08: d6fxnq1, d6fxnq2
Chain 'R':
Compound: belimumab light chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 6FXN
Domains in SCOPe 2.08: d6fxnr1, d6fxnr2
Heterogens: HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>6fxnA (A:)
mrgshhhhhhgsavqgpeetvtqdclqliadsetptiqkgsytfvpwllsfkrgsaleek
enkilvketgyffiygqvlytdktyamghliqrkkvavfgdelslvtlfrciqnmpetlp
nnscysagiakleegdelqlaiprenaqisldgdvtffgalkll